Bohlin Anna Margareta, Olsen Susanne Nautrup, Laursen Sigrid Hyldahl, Öhman Anna, van Galen Gaby
Evidensia Equine Specialist Hospital Helsingborg, Bergavägen 3, 254 66, Helsingborg, Sweden.
Large Animal Teaching Hospital, Department of Veterinary Clinical Sciences, University of Copenhagen, Agrovej 8, 2630, Taastrup, Denmark.
Acta Vet Scand. 2019 Mar 8;61(1):12. doi: 10.1186/s13028-019-0447-3.
Lawsonia intracellularis, an obligate intracellular bacterium, causes equine proliferative enteropathy, mainly in horses around weaning. This disease is rarely reported in the Scandinavian countries.
Five cases of equine proliferative enteropathy were diagnosed between 2008-2016 at the University of Copenhagen Large Animal Teaching Hospital. Cases were Danish Warmbloods and a Friesian horse, aged 6-7 months, presenting with typical clinical signs of lethargy, poor body condition, pyrexia and diarrhea. Clinical pathology was consistent with previous reports of severe hypoalbuminemia and leukocytosis. Diagnosis was confirmed by fecal polymerase chain reaction, serum immunomonolayer peroxidase assay and/or immunofluorescence and fluorescence in situ hybridization performed on formalin-fixed ileum samples. Concurrent intestinal parasitism was present in all five cases. Treatment consisted of antimicrobial therapy, anti-inflammatories, intravenous crystalloids and plasma. Three foals were euthanised due to deterioration and poor response to treatment, one with complications of septic arthritis and Strongylus vulgaris associated intestinal infarct. The other two foals survived and were reported by the owners to be healthy on long-term follow-up.
Equine proliferative enteropathy is a disease to consider in young horses presenting with diarrhea and hypoproteinemia in Denmark.
胞内劳森菌是一种专性胞内细菌，可引起马增生性肠炎，主要发生在断奶前后的马匹中。这种疾病在斯堪的纳维亚国家很少有报道。
2008年至2016年间，哥本哈根大学大型动物教学医院诊断出5例马增生性肠炎病例。病例包括丹麦温血马和一匹弗里斯兰马，年龄在6至7个月之间，表现出典型的临床症状，如嗜睡、身体状况不佳、发热和腹泻。临床病理学与先前报道的严重低白蛋白血症和白细胞增多症一致。通过粪便聚合酶链反应、血清免疫单层过氧化物酶测定和/或免疫荧光以及对福尔马林固定的回肠样本进行荧光原位杂交来确诊。所有5例病例均同时存在肠道寄生虫感染。治疗包括抗菌治疗、抗炎药、静脉输注晶体液和血浆。3只幼驹因病情恶化和对治疗反应不佳而实施安乐死，其中1只伴有化脓性关节炎和普通圆线虫相关的肠道梗死并发症。另外2只幼驹存活下来，主人报告称在长期随访中健康状况良好。
在丹麦，对于出现腹泻和低蛋白血症的幼马，马增生性肠炎是一种需要考虑的疾病。
