Bastard D P, Bollea-Garlatti M L, Belatti A, Puga M C, Hernández M N, Mazzuoccolo L D
Departamento de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Departamento de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Actas Dermosifiliogr (Engl Ed). 2019 Apr;110(3):206-211. doi: 10.1016/j.ad.2018.12.004. Epub 2019 Mar 6.
Breast cancer is the most common cause of cutaneous metastases. In our review of the literature, we found no studies that have investigated the prevalence of cutaneous metastases from breast cancer in Latin America or compared survival in relation to the site of cutaneous involvement or the presence of visceral metastases. The aims of this study were to characterize the prevalence and clinical features of cutaneous metastases from breast cancer and analyze survival in relation to site of involvement and the concomitant presence of visceral metastases.
Retrospective cohort study. We evaluated patients with breast cancer and histologically confirmed cutaneous metastases.
Data from 914 patients with breast cancer seen between 2007 and 2014 were analyzed. Thirty-one of the patients, all women, had cutaneous metastases (prevalence, 3.4%; 95% CI, 2.3%-4.7%). The most common form of metástasis was nodular, metachronous, and asymptomatic. There were discrepancies between the immunohistochemical findings for the primary tumor and the metastases in 5 of 21 women. The metastases were locorregional in 23 patients and distant in 8. No differences were observed between patients with locorregional and distant metastases for survival after diagnosis of the primary tumor (median of 4.7 vs. 4.8 years; P=.085) or the cutaneous metastases (median of 2.9 vs. 1.1 years, P=.06). Women with a simultaneous diagnosis of cutaneous and visceral metastases had the shortest survival.
This is the first study in Latin America to estimate the prevalence of cutaneous metastases from breast cancer and we found it to be lower than rates reported for other parts of the world.
乳腺癌是皮肤转移最常见的病因。在我们对文献的回顾中，未发现有研究调查拉丁美洲乳腺癌皮肤转移的患病率，或比较与皮肤受累部位或内脏转移存在情况相关的生存率。本研究的目的是描述乳腺癌皮肤转移的患病率和临床特征，并分析与受累部位及内脏转移并存情况相关的生存率。
回顾性队列研究。我们评估了患有乳腺癌且经组织学证实有皮肤转移的患者。
分析了2007年至2014年间诊治的914例乳腺癌患者的数据。其中31例患者（均为女性）有皮肤转移（患病率为3.4%；95%置信区间为2.3%-4.7%）。最常见的转移形式为结节状、异时性且无症状。21例女性中有5例原发肿瘤与转移灶的免疫组化结果存在差异。23例患者的转移为局部区域性，8例为远处转移。在原发性肿瘤诊断后，局部区域性转移和远处转移患者的生存率无差异（中位数分别为4.7年和4.8年；P = 0.085），皮肤转移后的生存率也无差异（中位数分别为2.9年和1.1年，P = 0.06）。同时诊断有皮肤和内脏转移的女性生存期最短。
这是拉丁美洲第一项估计乳腺癌皮肤转移患病率的研究，我们发现其患病率低于世界其他地区报道的患病率。
