甲状腺激素对肉鸡生长激素分泌的影响。

Effect of thyroid hormones on growth hormone secretion in broiler chickens.

作者信息

Scanes C G, Denver R J, Bowen S J

出版信息

Poult Sci. 1986 Feb;65(2):384-90. doi: 10.3382/ps.0650384.

Abstract

Plasma concentrations of growth hormone (GH) were observed to be significantly elevated following the administration of thyrotropin-releasing hormone (TRH) in young (4- to 12-week-old) but not in adult (20-week-old) broiler chickens. However, adult sex-linked (dw) dwarf hens did respond to TRH. Treatment with triiodothyronine (T3) but not thyroxine (T4) (at 1 ppm in the diet from hatch) consistently and significantly reduced the growth rate and decreased the plasma concentrations of GH following TRH injection in normal (DwDw males or Dw-females), hemizygous dwarf (dw-) female, and heterozygous (Dwdw) male lines of broiler chickens. Similarly, T3 was significantly more effective than T4 in inhibiting the increase in plasma concentrations of GH following TRH injection in broiler chicks made hypothyroid by methimazole administration.

摘要

在4至12周龄的幼龄肉鸡中，观察到注射促甲状腺激素释放激素（TRH）后生长激素（GH）的血浆浓度显著升高，但在20周龄的成年肉鸡中未出现这种情况。然而，成年性连锁（dw）矮小型母鸡对TRH有反应。在正常（DwDw雄性或Dw雌性）、半合子矮小型（dw-）雌性和杂合子（Dwdw）雄性品系的肉鸡中，从孵化开始在日粮中添加1 ppm的三碘甲状腺原氨酸（T3）而非甲状腺素（T4），持续且显著降低了生长速度，并在注射TRH后降低了GH的血浆浓度。同样，在通过给予甲巯咪唑造成甲状腺功能减退的肉鸡雏鸡中，T3在抑制注射TRH后GH血浆浓度升高方面比T4显著更有效。