促甲状腺激素释放激素可诱导成年甲状腺功能减退家禽分泌生长激素。
Thyrotrophin-releasing hormone induces growth hormone secretion in adult hypothyroid fowl.
作者信息
Harvey S, Scanes C G, Klandorf H
机构信息
Department of Physiology, University of Alberta, Edmonton, Canada.
出版信息
Gen Comp Endocrinol. 1988 Feb;69(2):233-7. doi: 10.1016/0016-6480(88)90010-x.
While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3). Moreover, whereas GH secretion in conscious adult birds was poorly responsive to TRH stimulation, conscious birds made hypothyroid by goitrogen pretreatment (with propylthiouracil, methimazole, or thiourea) were responsive to TRH challenge. Basal circulating GH concentrations in the goitrogen-pretreated birds were also higher than in the vehicle-injected controls. Surgical thyroidectomy similarly increased the basal GH concentration in adult birds and promoted TRH-induced GH secretion. These results demonstrate inhibitory effects of the thyroid hormones on basal and stimulated GH secretion in adult domestic fowl and suggest that GH release in adults is partly under tonic thyroidal inhibition.
虽然促甲状腺激素释放激素（TRH）能刺激成年麻醉公鸡的生长激素（GH）分泌，但在预先用甲状腺素（T4）或三碘甲状腺原氨酸（T3）处理的麻醉鸡中，GH反应被阻断。此外，成年清醒鸡的GH分泌对TRH刺激反应不佳，而通过用致甲状腺肿物质（丙硫氧嘧啶、甲巯咪唑或硫脲）预处理造成甲状腺功能减退的清醒鸡对TRH刺激有反应。致甲状腺肿物质预处理鸡的基础循环GH浓度也高于注射赋形剂的对照组。手术切除甲状腺同样增加了成年鸡的基础GH浓度，并促进了TRH诱导的GH分泌。这些结果证明了甲状腺激素对成年家禽基础和刺激的GH分泌具有抑制作用，并表明成年家禽的GH释放部分受甲状腺的紧张性抑制。
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