Snyder P B, Galanopoulos V K, Kafatos F C
Proc Natl Acad Sci U S A. 1986 May;83(10):3341-5. doi: 10.1073/pnas.83.10.3341.
We report on the characterization of five third chromosome mutations with strong effects on the formation of the eggshell or chorion. Three mutations, defining two loci, result in substantially reduced follicle cell-specific amplification of the major chorion structural genes and, hence, in underproduction of the corresponding mRNAs and proteins. The other two mutations, though displaying structural chorion abnormalities, appear to have no significant effect on amplification and to express normally the major chorion structural genes. The possible nature of these mutations is discussed.
我们报道了五个对卵壳或绒毛膜形成有强烈影响的第三染色体突变的特征。三个突变（定义了两个基因座）导致主要绒毛膜结构基因的卵泡细胞特异性扩增显著减少，因此相应的mRNA和蛋白质产量不足。另外两个突变虽然表现出绒毛膜结构异常，但似乎对扩增没有显著影响，并且主要绒毛膜结构基因正常表达。我们讨论了这些突变可能的性质。
