Kaplan G, Witmer M D, Nath I, Steinman R M, Laal S, Prasad H K, Sarno E N, Elvers U, Cohn Z A
Proc Natl Acad Sci U S A. 1986 May;83(10):3469-73. doi: 10.1073/pnas.83.10.3469.
The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubled in 48-72 hr, and this was attributed to increases in both size and number of keratinocytes. In addition, the phenotype of the keratinocytes changed from Ia- to Ia+. Similar changes in keratinocyte Ia-antigen expression occurred in the epidermis overlying untreated tuberculoid leprosy and cutaneous leishmaniasis lesions, but not in lepromatous leprosy. We suggest that one or more epidermal growth factors may be generated in the course of a delayed immune reaction in the dermis.
人类皮肤免疫反应中发生的表皮变化已在结核菌素反应、结核样型麻风及瘤型麻风皮损以及皮肤利什曼病中得到研究。在每种情况下，真皮中都有单核细胞和T细胞聚集，且表皮出现增厚。在结核菌素反应中，表皮厚度在48 - 72小时内有时会翻倍，这归因于角质形成细胞大小和数量的增加。此外，角质形成细胞的表型从Ia - 变为Ia +。在未经治疗的结核样型麻风及皮肤利什曼病皮损上方的表皮中，角质形成细胞Ia抗原表达也出现类似变化，但在瘤型麻风皮损中未出现。我们认为，在真皮延迟免疫反应过程中可能会产生一种或多种表皮生长因子。
