Brunozzi Denise, Alaraj Ali
Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois.
Oper Neurosurg. 2019 Dec 1;17(6):E248. doi: 10.1093/ons/opz029.
N-butyl cyanoacrylate glue (n-BCA, Cerenovus, Irvine, California) is commonly used to treat arteriovenous malformation (AVM). Even though Onyx (ethylene vinyl alcohol, Medtronic, Dublin, Ireland) presents more controlled injection, n-BCA is colorless, thus preferable for treatment of superficial facial malformations. N-BCA injection into AVM can result in premature distal migration or early precipitation and reflux into the feeder vessels. Here we describe a trans-arterial balloon assisted technique embolization of a complex facial AVM with n-BCA. A 22-yr-old female with chronic oral/gum bleeding presented with a complex facial AVM. She underwent selective transarterial n-BCA balloon assisted treatment with dextrose push. Informed written consent was obtained. A Scepter dual lumen balloon (MicroVention, Aliso Viejo, California) and a Prowler microcatheter (Cerenovus) were introduced via a 6-French Envoy guide catheter (Cerenovus) selectively into the AVM feeder. The balloon was positioned 3 cm proximal to the Prowler microcatheter tip and fully inflated to create flow arrest. Diluted 25% concentration of n-BCA in Ethiodol Oil was injected through the Prowler microcatheter. The distal migration of the n-BCA was modulated with simultaneous injection of Dextrose 5% in water via the Scepter balloon. This resulted in a controlled glue injection without early distal glue migration (because of the flow arrest) nor early proximal glue precipitation or reflux (because of the dextrose infusion), obtaining complete cure of the complex facial AVM. Glue embolization with flow arrest and dextrose push allows well controlled injection, and it represents a valid option also for high flow vascular lesions.
氰基丙烯酸正丁酯胶水(n-BCA,Cerenovus公司,加利福尼亚州欧文市)常用于治疗动静脉畸形(AVM)。尽管Onyx(乙烯-乙烯醇共聚物,美敦力公司,爱尔兰都柏林)的注射更可控,但n-BCA是无色的,因此更适合治疗面部浅表畸形。将n-BCA注入AVM可导致过早的远端迁移或早期沉淀并反流至供血血管。在此,我们描述一种经动脉球囊辅助技术,使用n-BCA栓塞复杂的面部AVM。一名22岁慢性口腔/牙龈出血的女性患有复杂的面部AVM。她接受了选择性经动脉n-BCA球囊辅助治疗并推注葡萄糖。已获得知情书面同意。通过6法国Envoy引导导管(Cerenovus公司)将Scepter双腔球囊(MicroVention公司,加利福尼亚州阿利索维耶霍市)和Prowler微导管(Cerenovus公司)选择性地插入AVM供血血管。球囊置于Prowler微导管尖端近端3 cm处并完全充盈以实现血流阻断。通过Prowler微导管注入在碘油中稀释至25%浓度的n-BCA。通过Scepter球囊同时注入5%葡萄糖水溶液来调节n-BCA的远端迁移。这导致胶水注射可控,既没有早期远端胶水迁移(由于血流阻断),也没有早期近端胶水沉淀或反流(由于葡萄糖输注),从而使复杂的面部AVM完全治愈。采用血流阻断和推注葡萄糖的胶水栓塞术可实现良好控制的注射,对于高流量血管病变也是一种有效的选择。