Department of Neurology, Dokuz Eylül University Medical School, 35340 Izmir, Turkey; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, 35340 Izmir, Turkey; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, 35340 Izmir, Turkey.
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, 35340 Izmir, Turkey.
Int J Psychophysiol. 2019 May;139:48-58. doi: 10.1016/j.ijpsycho.2019.03.002. Epub 2019 Mar 7.
Event-related oscillatory responses reflect the cognitive status in many neuropsychiatric conditions including mild cognitive impairment (MCI). In this study, a total of 30 patients with amnestic MCI (aMCI) and 25 patients with MCI of Parkinson's disease (PD-MCI) were compared with 28 aged-, gender-, education-matched healthy control (HC) participants using visual event-related delta, theta, alpha oscillatory responses by methods of event-related spectral perturbation and inter-trial coherence. PD-MCI and aMCI groups commonly share a decreased theta power, but all electrophysiological deviations from the controls were more prominent in PD-MCI than aMCI in all frequency bands. Additionally, decreased phase-locking in all studied frequency bands was encountered only in PD-MCI group, but it was preserved in aMCI. These findings indicate that visual networks in PD-MCI are more severely affected than aMCI. Reduced phase-locking in PD-MCI may possibly relate to dysfunctioning subcortical modulating centers that take a role in the generation of event-related responses.
事件相关的振荡反应反映了许多神经精神疾病的认知状态，包括轻度认知障碍（MCI）。在这项研究中，我们将 30 名遗忘型 MCI（aMCI）患者和 25 名帕金森病 MCI（PD-MCI）患者与 28 名年龄、性别、教育程度相匹配的健康对照（HC）参与者进行了比较，使用事件相关光谱微扰和试验间相干性的方法比较了视觉事件相关的 delta、theta、alpha 振荡反应。PD-MCI 和 aMCI 组通常都表现出 theta 功率降低，但与 aMCI 相比，所有电生理异常在所有频段都更明显。此外，仅在 PD-MCI 组中观察到所有研究频段的相位锁定降低，但在 aMCI 中则保留。这些发现表明，PD-MCI 中的视觉网络比 aMCI 受到更严重的影响。PD-MCI 中相位锁定的降低可能与功能失调的皮质下调节中心有关，这些中心在事件相关反应的产生中起作用。
