Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Int J Pharm. 2019 May 1;562:187-202. doi: 10.1016/j.ijpharm.2019.02.045. Epub 2019 Mar 6.
The drug nanocrystals (NCs) with unique physicochemical properties are now considered as a promising drug delivery system for poorly water-soluble drugs. So far >20 formulations of NCs have been approved in the market. In this review, we summarized recent advances of NCs with emphasis on their therapeutic applications based on administration route and disease states. At the end, we present a brief description of the future perspectives of NCs and their potential role as a promising drug delivery system. As a strategy for solubilization and bioavailability enhancement, the NCs have gained significant success. Besides this, the function of NCs is still far from developed. The emerging NC-based drug delivery approach would widen the applications of NCs in drug delivery and bio-medical field. Their in vitro and in vivo fate is extremely unclear; and the development of hybrid NCs with environment-sensitive fluorophores may assist to extend the scope of bio-imaging and provide better insight to their intracellular uptake kinetics, in vitro and in vivo.
药物纳米晶体（NCs）具有独特的物理化学性质，目前被认为是一种有前途的难溶性药物给药系统。迄今为止，已有超过 20 种 NCs 制剂在市场上获得批准。在这篇综述中，我们总结了 NCs 的最新进展，重点介绍了基于给药途径和疾病状态的治疗应用。最后，我们简要描述了 NCs 的未来展望及其作为一种有前途的药物给药系统的潜在作用。作为增溶和提高生物利用度的策略，NCs 已经取得了显著的成功。除此之外，NCs 的功能仍远未得到开发。新兴的基于 NC 的药物递送方法将拓宽 NCs 在药物递送和生物医学领域的应用。它们在体外和体内的命运极不清楚；并且开发具有环境敏感性荧光团的混合 NCs 可能有助于扩大生物成像的范围，并提供对其细胞内摄取动力学的更好了解，以及在体外和体内的情况。
