Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Prédio Anexo, Porto Alegre, Rio Grande do Sul 90035-903, Brazi.
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Prédio Anexo, Porto Alegre, Rio Grande do Sul 90035-903, Brazi; Department of Pharmacology, Programa de Pós-Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Psychiatry Res. 2019 Apr;274:345-351. doi: 10.1016/j.psychres.2019.02.046. Epub 2019 Feb 20.
Maltreatments in childhood may have implications for neurodevelopment that could remain throughout life. Childhood trauma seems to be associated with the onset of bipolar disorder (BD), and its occurrence might accentuate the overall disease impairments related to cognitive deficits in BD. We aimed to evaluate the effects of a history of childhood trauma to estimated intellectual functioning (IQ) of individuals with BD. We included 72 subjects with BD during euthymia. Participants underwent a clinical interview and were assessed through the Childhood Trauma Questionnaire (CTQ) and Wechsler Abbreviated Scale of Intelligence (WASI). Most prevalent trauma subtypes were emotional abuse and neglect (54.1%). A linear regression model that included perceived childhood trauma, family history of severe mental disorders, age at diagnosis and psychotic symptoms during the first episode as main factors showed that only childhood trauma had a significant effect in predicting estimated IQ. Therefore, the history of childhood trauma in individuals with BD may play a role in intellectual development, suggesting that adversities during development result in decreased general cognitive abilities. These results reinforce the need to promote early interventions to protect childhood and to promote the well-being of children, contributing to the growth of healthy adults.
儿童时期的虐待行为可能对神经发育产生影响，并可能持续一生。儿童创伤似乎与双相情感障碍（BD）的发病有关，其发生可能会加重与 BD 认知缺陷相关的整体疾病损害。我们旨在评估儿童期创伤史对 BD 个体智力功能（智商）的影响。我们纳入了 72 名处于缓解期的 BD 患者。参与者接受了临床访谈，并通过儿童期创伤问卷（CTQ）和韦氏简明智力量表（WASI）进行评估。最常见的创伤亚型是情感虐待和忽视（54.1%）。一个包含感知到的儿童期创伤、严重精神障碍家族史、诊断时年龄和首发时精神病症状的线性回归模型显示，只有儿童期创伤对预测估计智商有显著影响。因此，BD 患者的儿童期创伤史可能在智力发展中发挥作用，表明发育过程中的逆境会导致一般认知能力下降。这些结果强调了需要促进早期干预措施，以保护儿童和促进儿童福祉，促进健康成年人的成长。
