Division of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea.
Division of Functional Food Research, Korea Food Research Institute, Wanju-gun, Republic of Korea.
Int Immunopharmacol. 2019 May;70:235-240. doi: 10.1016/j.intimp.2019.02.040. Epub 2019 Mar 6.
Inflammatory bowel diseases (IBD) induce inflammation in the colon and small intestine. IBD include ulcerative colitis and Crohn's disease, with such common symptoms as severe diarrhea, fever, and blood in the stool. In the current study, we explored the ability of peanut shell extract (PSE) to alleviate IBD in an experimental colonic inflammation model. Colitis was induced by orally administered dextran sulfate sodium (DSS) in mice. Peanut shell extract was prepared using a method of aqueous ethanol. DSS treatment reduced the colon length and mouse body weight, and aggravated disease condition compared with untreated control mice. Oral administration of 400 mg/kg PSE alleviated colon shortening, body weight loss, DAI, and colon injury score in DSS-induced colitis. These physiological improvements were validated by reduced levels of proinflammatory cytokines and infiltrating macrophage accumulation in the inflamed colon in the PSE administered group. These observations suggest that PSE may be developed as an alternative natural extract for the prevention or treatment of IBD.
炎症性肠病 (IBD) 会引起结肠和小肠炎症。IBD 包括溃疡性结肠炎和克罗恩病，其常见症状为严重腹泻、发热和粪便中有血。在目前的研究中，我们探讨了花生壳提取物 (PSE) 在实验性结肠炎症模型中缓解 IBD 的能力。通过给小鼠口服葡聚糖硫酸钠 (DSS) 诱导结肠炎。采用水乙醇法制备花生壳提取物。与未处理的对照小鼠相比，DSS 处理会缩短结肠长度和降低小鼠体重，并加重疾病状况。口服 400mg/kg 的 PSE 可缓解 DSS 诱导的结肠炎引起的结肠缩短、体重减轻、DAI 和结肠损伤评分。在 PSE 给药组中，促炎细胞因子水平降低和浸润巨噬细胞积聚减少，验证了这些生理改善。这些观察结果表明，PSE 可能被开发为预防或治疗 IBD 的替代天然提取物。
