Vizza Enrico, Mancini Emanuela, Laquintana Valentina, Loria Rossella, Carosi Mariantonia, Baiocco Ermelinda, Cicchillitti Lucia, Piaggio Giulia, Patrizi Lodovico, Sperduti Isabella, Zampa Ashanti, Cutillo Giuseppe, Falcioni Rita, Corrado Giacomo
Department of Experimental Clinical Oncology, Gynecologic Oncology Unit, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Department of Research, Advanced Diagnostics and Technological Innovation, Area of Translational Research, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
Surg Oncol. 2019 Mar;28:151-157. doi: 10.1016/j.suronc.2019.01.001. Epub 2019 Jan 5.
The aim of this study was to evaluate the prognostic role of positive peritoneal cytology (PPC) in a cohort of patients with endometrial cancer (EC). The secondary objective was to correlate the PPC and the expression of L1CAM in a group of patients with recurrence endometrial disease.
All women diagnosed with EC and who performed a peritoneal cytology at "Regina Elena" National Cancer Institute of Rome from 2001 to 2013 were included in the study. Patients were divided into two groups according to positivity at peritoneal cytology. Moreover, patients with a recurrence disease and whose a tissue microarray (TMA) tumor sample was available underwent a L1CAM analysis.
Seven hundred sixty six patients underwent to EC staging in our Institute: 696 (90.8%) with negative and 70 (9.2%) with positive cytology. Five-year recurrence rate was higher in women with PPC (46.9% vs 18.4%, p = 0 < 0.0001) and, in particular, distant recurrence (86.7% vs 53.4%, p = 0.03). Moreover, we found an interesting pattern of recurrence disease in the group of early stage of EC with NPC and positive L1CAM.
Our results support the data that PPC may be a potential prognostic factor in early EC, due to its significant association with other risk factors and its significant influence on survival. Our findings confirm the need for large studies that point out the role of PPC and new prognostic factors, including biomarkers as L1CAM.
本研究旨在评估阳性腹膜细胞学检查（PPC）在一组子宫内膜癌（EC）患者中的预后作用。次要目的是在一组复发性子宫内膜疾病患者中关联PPC与L1CAM的表达。
纳入2001年至2013年在罗马“雷吉娜·埃琳娜”国家癌症研究所被诊断为EC且进行了腹膜细胞学检查的所有女性。根据腹膜细胞学检查的阳性情况将患者分为两组。此外，对有复发性疾病且有组织微阵列（TMA）肿瘤样本的患者进行L1CAM分析。
766例患者在我们研究所接受了EC分期：696例（90.8%）细胞学检查为阴性，70例（9.2%）为阳性。PPC患者的五年复发率更高（46.9%对18.4%，p = 0 < 0.0001），尤其是远处复发（86.7%对53.4%，p = 0.03）。此外，我们在早期EC伴NPC和L1CAM阳性的患者组中发现了一种有趣的复发疾病模式。
我们的结果支持以下数据，即PPC可能是早期EC的潜在预后因素，因为它与其他风险因素有显著关联且对生存有显著影响。我们的研究结果证实需要开展大型研究以明确PPC和新的预后因素（包括作为生物标志物的L1CAM）的作用。
