Iwaki Hirotaka, Jin Kazutaka, Sugawara Norio, Nakasato Nobukazu, Kaneko Sunao
North Tohoku Epilepsy Center, Minato Hospital, Hachinohe, Aomori, Japan; Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Epilepsy Res. 2019 May;152:1-6. doi: 10.1016/j.eplepsyres.2019.02.011. Epub 2019 Feb 25.
Body weight (BW) gain may be induced by perampanel (PER) administration, similar to the well-known adverse effects of valproic acid and gabapentin. Intellectual disability (ID) and serum PER concentration may be risk factors of BW gain.
This study investigated how ID and serum PER concentration are associated with PER-induced BW gain.
Subjects were 76 patients with epilepsy (41 men, aged 16-70 years). All patients were divided by intelligence quotient (IQ) into no ID (IQ ≥ 70, n = 24), mild to moderate ID (70 > IQ ≥35, n = 31), and severe to profound ID (IQ < 35, n = 21) groups. BW was measured before and 2, 4, 6, and 12 months after initiation of PER treatment, and serum PER concentration at 12 months.
BW gains in the mild to moderate ID group at 4, 6, and 12 months were significantly (p < 0.05) higher than in the no ID and in the severe to profound ID groups. At 12 months, BW gain was associated with serum PER concentrations in the no ID (p = 0.034) and the mild to moderate ID (p = 0.001) groups but not in the severe to profound ID group. Multiple linear regression analysis found BW gain at 12 months was positively correlated with the mild to moderate ID group (β = 0.373, p = 0.002) and serum PER concentration (β = 0.241, p = 0.047).
The mild to moderate ID group gained more BW than the no ID group, suggesting that PER-induced food intake was greater due to weaker behavioral control in the mild to moderate ID group. The present study suggests a linear correlation between serum PER concentration and BW change.
与丙戊酸和加巴喷丁的众所周知的不良反应类似，服用吡仑帕奈（PER）可能会导致体重（BW）增加。智力残疾（ID）和血清PER浓度可能是体重增加的风险因素。
本研究调查了智力残疾和血清PER浓度与PER引起的体重增加之间的关联。
研究对象为76例癫痫患者（41名男性，年龄16 - 70岁）。所有患者根据智商（IQ）分为无智力残疾组（IQ≥70，n = 24）、轻度至中度智力残疾组（70＞IQ≥35，n = 31）和重度至极重度智力残疾组（IQ＜35，n = 21）。在开始PER治疗前以及治疗后2、4、6和12个月测量体重，并在12个月时测量血清PER浓度。
轻度至中度智力残疾组在4、6和12个月时的体重增加显著高于（p＜0.05）无智力残疾组和重度至极重度智力残疾组。在12个月时，无智力残疾组（p = 0.034）和轻度至中度智力残疾组（p = 0.001）的体重增加与血清PER浓度相关，而重度至极重度智力残疾组则不然。多元线性回归分析发现，12个月时的体重增加与轻度至中度智力残疾组（β = 0.373，p = 0.002）和血清PER浓度（β = 0.241，p = 0.047）呈正相关。
轻度至中度智力残疾组比无智力残疾组体重增加更多，这表明由于轻度至中度智力残疾组行为控制较弱，PER引起的食物摄入量更大。本研究表明血清PER浓度与体重变化之间存在线性相关性。
