Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy,
Neuroendocrinology. 2019;109(1):34-41. doi: 10.1159/000499470. Epub 2019 Mar 11.
The discovery of dopamine inhibitory effects on prolactin secretion has led to an era of successful dopaminergic therapy for prolactinomas. Herein we provide an overview of the evolution of dopamine agonists and their use in patients with PRL-secreting pituitary tumors, starting from the 1970s up to today, highlighting that normalization of PRL levels, restoration of eugonadism, and reduction of tumor mass can be achieved in the majority of patients by treatment with dopamine agonists.
多巴胺对催乳素分泌的抑制作用的发现开创了催乳素瘤多巴胺能治疗的成功时代。在此，我们回顾了多巴胺激动剂的发展历程及其在泌乳素分泌型垂体瘤患者中的应用，从 20 世纪 70 年代至今，重点强调大多数患者通过多巴胺激动剂治疗可以实现催乳素水平正常化、性腺功能恢复正常以及肿瘤体积缩小。
