Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis.
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Am J Clin Pathol. 2019 May 3;151(6):613-621. doi: 10.1093/ajcp/aqz006.
Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC).
A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases.
The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively.
The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.
需要进行多机构研究来验证《米兰唾液腺细胞病理学报告系统》（MSRSGC）。
在 12 年的时间里，从两个机构共检索了 1560 例唾液腺细针抽吸术。根据 MSRSGC 对诊断进行重新分类。根据 694 例组织学随访病例，计算每个类别的恶性风险（ROM）。
每个类别的 ROM 分别为：非诊断性为 18.3%，非肿瘤性为 8.9%，意义未确定的不典型性为 37.5%，良性肿瘤为 2.9%，唾液腺肿瘤恶性潜能不确定为 40.7%，疑似恶性为 100%，恶性为 98.3%。敏感性、特异性、阳性预测率和阴性预测率分别为 89%、99%、98%和 96%。
当前研究结果与 MSRSGC 一致。不典型性和不确定恶性潜能的不确定类别分别显示出 37.5%和 40.7%的中间 ROM。
