Nussey S S, Bevan D H, Ang V T, Jenkins J S
Thromb Haemost. 1986 Feb 28;55(1):34-6.
To study the possible role of arginine vasopressin (AVP) in the control of haemostasis AVP infusions at 3 doses (0.1, 0.2 and 0.3 mU/kg/min) were performed in 6 male volunteers. Both plasma and platelet AVP concentrations rose in a dose-related manner. At doses of 0.2 and 0.3 mU/kg/min there was an increase in the plasma concentrations of both plasma Factor VIII and von Willebrand factor. The data support the hypothesis that AVP, by interacting with platelets and stimulating factor VIII and von Willebrand factor release, plays a role in the control of haemostasis.
为研究精氨酸加压素（AVP）在止血控制中的可能作用，对6名男性志愿者进行了3种剂量（0.1、0.2和0.3 mU/kg/分钟）的AVP输注。血浆和血小板中的AVP浓度均呈剂量依赖性升高。在剂量为0.2和0.3 mU/kg/分钟时，血浆中凝血因子VIII和血管性血友病因子的浓度均有所增加。这些数据支持了以下假设：AVP通过与血小板相互作用并刺激凝血因子VIII和血管性血友病因子的释放，在止血控制中发挥作用。
