1 Clinical School of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
2 First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Acupunct Med. 2019 Apr;37(2):107-115. doi: 10.1177/0964528419828733. Epub 2019 Mar 11.
The aim of this study was to explore the effect of acupuncture stimulation at KI3 on brain glucose metabolism in spontaneously hypertensive rats (SHRs).
Brain glucose metabolism in SHRs after acupuncture stimulation at KI3 was detected using 18F-2-fluorodeoxy-D-glucose positron emission tomography (18F-FDG-PET). SHRs were randomly divided into three groups: no treatment (SHR group); acupuncture at KI3 (KI3 group); and sham acupuncture (Sham group). Wistar Kyoto (WKY) rats were used as a normal blood pressure (BP) control group. Rats were subjected to 10 min of acupuncture once a day for 7 days. BP and positron emission tomography-computed tomography (PET-CT) were measured after the first acupuncture session and after 7 days of treatment.
The results showed that BP was lower in the KI3 group than in the SHR group, both 30-60 min after the first acupuncture session and 24-48 h after the 7-day treatment. Compared with the WKY group, the SHR group had lower glucose metabolism in the motor cortex, sensory cortex, basal ganglia, corpus callosum, caudate putamen, and visual cortex. Compared with the untreated/sham-treated SHR control groups, cerebral glucose metabolism was lower in the medulla oblongata, thalamus, dorsal thalamus, orbital cortex, and hypothalamus after acupuncture at KI3, while it was higher in the olfactory cortex and inferior phrenic muscle.
Our results show that, in SHRs, needling at KI3 reduces high BP, most likely by altering the activation of cerebral regions.
本研究旨在探讨针刺肾经穴位（KI3）对自发性高血压大鼠（SHRs）脑葡萄糖代谢的影响。
采用 18F-2-氟代脱氧-D-葡萄糖正电子发射断层扫描（18F-FDG-PET）检测针刺 KI3 后 SHRs 的脑葡萄糖代谢。SHRs 随机分为 3 组：未治疗（SHR 组）；针刺 KI3（KI3 组）；假针刺（Sham 组）。Wistar Kyoto（WKY）大鼠作为正常血压（BP）对照组。大鼠每天接受 10 分钟针刺，连续 7 天。第一次针刺后和治疗 7 天后测量 BP 和正电子发射断层扫描计算机断层扫描（PET-CT）。
结果显示，针刺 KI3 后，KI3 组的 BP 低于 SHR 组，首次针刺后 30-60 分钟和 7 天治疗后 24-48 小时均如此。与 WKY 组相比，SHR 组运动皮层、感觉皮层、基底节、胼胝体、尾状核和视皮层的葡萄糖代谢较低。与未治疗/假处理的 SHR 对照组相比，针刺 KI3 后 SHR 延髓、丘脑、背丘脑、眶额皮质和下丘脑的脑葡萄糖代谢降低，而嗅皮质和膈下肌的脑葡萄糖代谢升高。
我们的结果表明，针刺 KI3 可降低 SHR 的高血压，可能是通过改变大脑区域的激活来实现的。
