Ouederni M, Sassi H, Nefaa F, Kharroubi A, Kellil N, Cheour M
Hôpital Habib Thameur, 3, rue A.Ben Ayed, 1089 Tunis, Tunisie; Faculté de médecine de Tunis, Université Tunis EL MANAR, Tunisie.
Hôpital Habib Thameur, 3, rue A.Ben Ayed, 1089 Tunis, Tunisie; Faculté de médecine de Tunis, Université Tunis EL MANAR, Tunisie.
J Fr Ophtalmol. 2019 Mar;42(3):255-261. doi: 10.1016/j.jfo.2018.09.010. Epub 2019 Mar 8.
The purpose of our study was to describe the microvascular abnormalities on OCT-angiography in eyes with branch retinal vein occlusion (BRVO), to measure the surface of the foveal avascular zone (FAZ) and the capillary density, and to establish anatomic-functional correlations.
We conducted an observational prospective study in the ophthalmology department of Habib Thameur Hospital in Tunis, which included 17 eyes of patients with unilateral BRVO. We studied the microvascular abnormalities and areas of capillary non-perfusion in the deep and superficial capillary plexuses (DCP, SCP). The area of the FAZ was measured in the SCP and correlated to visual acuity. The foveal and parafoveal capillary density was measured with flow quantification software.
The mean patient age was 57.94 ±18.04 years. Male:female ratio was approximately 1. Fourteen eyes (82.4%) showed cystoid macular edema which was significantly correlated to poor visual acuity (P=0.02). Vascular congestion was present in 12 eyes (70.60%) in the DCP and 8 eyes (47.1%) in the SCP. Intraretinal loops were found in 5 eyes (29.4%) in the DCP and 8 eyes (47.1%) in the SCP. Thirteen eyes (76.5%) exhibited vascular tortuosity in the DCP, and 14 eyes (82.4%) in the SCP. Areas of capillary non-perfusion were observed in 12 eyes (70.60%). The mean area of the FAZ was 617.53±525.75μ in eyes with BRVO. Enlargement of the FAZ was correlated to visual loss (P=0.01). Mean foveal capillary density was 15.49% (±5.18%), and mean peripheral capillary density was 44% (±4.75%). There was no correlation between vascular density and visual acuity in our series.
OCT-angiography is part of the current diagnostic workup for RVO. It has a relevant role in establishing a prognosis by studying the area of the FAZ and the capillary density.
我们研究的目的是描述视网膜分支静脉阻塞（BRVO）患者眼部光学相干断层扫描血管造影（OCT-angiography）的微血管异常情况，测量黄斑无血管区（FAZ）的面积和毛细血管密度，并建立解剖学与功能之间的相关性。
我们在突尼斯哈比卜·塔穆尔医院眼科进行了一项前瞻性观察研究，纳入了17例单侧BRVO患者的眼部。我们研究了深层和浅层毛细血管丛（DCP、SCP）中的微血管异常和毛细血管无灌注区域。在SCP中测量FAZ的面积，并将其与视力相关联。使用血流定量软件测量黄斑和黄斑旁的毛细血管密度。
患者的平均年龄为57.94±18.04岁。男女比例约为1。14只眼（82.4%）出现黄斑囊样水肿，这与视力差显著相关（P=0.02）。12只眼（70.60%）的DCP存在血管充血，8只眼（47.1%）的SCP存在血管充血。5只眼（29.4%）的DCP发现视网膜内血管环，8只眼（47.1%）的SCP发现视网膜内血管环。13只眼（76.5%）的DCP出现血管迂曲，14只眼（82.4%）的SCP出现血管迂曲。12只眼（70.60%）观察到毛细血管无灌注区域。BRVO患者眼部FAZ的平均面积为617.53±525.75μ。FAZ扩大与视力丧失相关（P=0.01）。黄斑平均毛细血管密度为15.49%（±5.18%），周边平均毛细血管密度为44%（±4.75%）。在我们的研究系列中，血管密度与视力之间无相关性。
OCT血管造影是目前视网膜静脉阻塞诊断检查的一部分。通过研究FAZ面积和毛细血管密度，它在判断预后方面具有重要作用。
