Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University.
Beijing Institute of Heart Lung and Blood Vessel Disease.
J Atheroscler Thromb. 2019 Oct 1;26(10):856-867. doi: 10.5551/jat.47043. Epub 2019 Mar 9.
Omentin-1, as a novel adipocytokine, ameliorates obesity-associated disorders and suppresses the development of atherosclerotic lesions. The present research investigated the correlation between serum omentin-1 and post-infarction myocardial function.
A total of 52 patients with first anterior ST-segment elevation myocardial infarction (STEMI) were recruited into this study. Participants were divided into two subgroups according to median admission omentin-1 concentration. δ1 was defined as (admission omentin-1 level) - (serum omentin-1 at 24 hours after admission) and δ2 was defined as (admission omentin-1 level) - (serum omentin-1 at 72 hours after admission). The change in left ventricular ejection fraction (LVEF) was regarded as (LVEF at 3 months post-STEMI)-(LVEF at 2 days post-STEMI).
Admission omentin-1 level was the highest, while omentin-1 decreased over the following 3 days. The high admission omentin-1 group had lower peak muscle brain fraction of creatine kinase (CK-MB). Additionally, the change in LVEF and the global LVEF at 3 months post-STEMI all ameliorated significantly in the high admission omentin-1 group. For the time-dependent change in omentin-1, there were negative associations among δ1, δ2, and peak CK-MB. δ1 and δ2 also correlated positively with LVEF at 3 months post-STEMI. Most importantly, δ1 (r =0.346, p=0.012) and δ2 (r =0.439, p=0.001) also correlated positively with the change in LVEF. After multivariate linear regression analysis, δ1 (Beta=0.026, 95% CI 0.011 to 0.041, p=0.001) and δ2 (Beta=0.024, 95% CI 0.009 to 0.038, p=0.003) also remained associated with the change in LVEF.
The admission omentin-1 and time-dependent change in omentin-1 level all have a significant correlation with the early improvement of post-infarction myocardial function. While only the time-dependent change in omentin-1 (δ1 and δ2) remained associated with the early improvement of post-infarction myocardial function after multivariate linear regression analysis. The present research indicated that omentin-1 represents a promising adipocytokine to retard negative cardiac remodeling after STEMI.
网膜素-1 作为一种新型脂肪细胞因子，可改善肥胖相关疾病并抑制动脉粥样硬化病变的发展。本研究旨在探讨血清网膜素-1 与梗死后心肌功能之间的相关性。
本研究共纳入 52 例首次前壁 ST 段抬高型心肌梗死（STEMI）患者。根据入院时网膜素-1 浓度中位数将患者分为两组。δ1 定义为（入院时网膜素-1 水平）-（入院后 24 小时血清网膜素-1 水平），δ2 定义为（入院时网膜素-1 水平）-（入院后 72 小时血清网膜素-1 水平）。左心室射血分数（LVEF）的变化被视为（STEMI 后 3 个月 LVEF）-（STEMI 后 2 天 LVEF）。
入院时网膜素-1 水平最高，随后在接下来的 3 天内逐渐下降。高入院网膜素-1 组的肌酸激酶同工酶（CK-MB）峰值较低。此外，高入院网膜素-1 组的 LVEF 变化和 STEMI 后 3 个月的整体 LVEF 均显著改善。对于网膜素-1 的时间依赖性变化，δ1、δ2 和 CK-MB 峰值之间呈负相关。δ1 和 δ2 与 STEMI 后 3 个月的 LVEF 也呈正相关。最重要的是，δ1（r=0.346，p=0.012）和 δ2（r=0.439，p=0.001）与 LVEF 的变化也呈正相关。多元线性回归分析后，δ1（Beta=0.026，95%CI 0.011 至 0.041，p=0.001）和 δ2（Beta=0.024，95%CI 0.009 至 0.038，p=0.003）与 LVEF 的变化仍相关。
入院时网膜素-1 水平和网膜素-1 水平的时间依赖性变化均与梗死后心肌功能的早期改善具有显著相关性。然而，只有网膜素-1 的时间依赖性变化（δ1 和 δ2）在多元线性回归分析后仍与梗死后心肌功能的早期改善相关。本研究表明，网膜素-1 作为一种有前途的脂肪细胞因子，可延缓 STEMI 后负性心脏重构。
