Mamun Md Abdullah Al, Faruk Md, Rahman Md Mizanur, Nahar Kamrun, Kabir Fariha, Alam Md Ashraful, Subhan Nusrat
Department of Pharmaceutical Sciences, North South University, Bangladesh.
Evid Based Complement Alternat Med. 2019 Feb 3;2019:1897237. doi: 10.1155/2019/1897237. eCollection 2019.
leaf is reported to contain many bioactive polyphenols which play an important role in the prevention and treatment of various diseases. Our investigation aimed to study the effect of leaf powder supplementation on obesity and liver status by using experimental rats. To study the effects of guava leaf supplementation in high fat diet induced obesity, rats were randomly divided into four experimental groups (n=7), control (group I), control + guava leaf (group II), HCHF (group III), and HCHF + guava leaf (group IV). At the end of the experimental period (56 days), glucose intolerance, liver enzymes activities, antioxidant enzymes activities, and lipid and cholesterol profiles were evaluated. Our results revealed that guava leaf powder supplementation showed a significant reduction in fat deposition in obese rats. Moreover, liver enzyme functions were increased in high fat diet fed rats compared to the control rats significantly which were further ameliorated by guava leaf powder supplementation in high fat diet fed rats. High fat diet feeding also decreased the antioxidant enzyme functions and increased the lipid peroxidation products compared to the control rats. Guava leaf powder supplementation in high fat diet fed rats reduced the oxidative stress markers and reestablished antioxidant enzyme system in experimental animals. Guava leaf powder supplementation in high fat diet fed rats also showed a relative decrease in inflammatory cells infiltration and collagen deposition in the liver compared to the high fat diet fed rats. The present study suggests that the supplementation of guava leaf powder prevents obesity, improves glucose intolerance, and decreases inflammation and oxidative stress in liver of high carbohydrate high fat diet fed rats.
据报道，树叶含有许多生物活性多酚，它们在预防和治疗各种疾病中发挥着重要作用。我们的研究旨在通过使用实验大鼠来研究补充树叶粉对肥胖和肝脏状态的影响。为了研究番石榴叶补充剂对高脂饮食诱导的肥胖的影响，将大鼠随机分为四个实验组（n = 7），对照组（I组）、对照 + 番石榴叶组（II组）、高碳水高脂肪组（III组）和高碳水高脂肪 + 番石榴叶组（IV组）。在实验期结束时（56天），评估葡萄糖耐量、肝酶活性、抗氧化酶活性以及脂质和胆固醇水平。我们的结果显示，补充番石榴叶粉可使肥胖大鼠的脂肪沉积显著减少。此外，与对照大鼠相比，高脂饮食喂养的大鼠肝酶功能显著增加，而高脂饮食喂养的大鼠补充番石榴叶粉后进一步改善了这种情况。与对照大鼠相比，高脂饮食喂养还降低了抗氧化酶功能并增加了脂质过氧化产物。高脂饮食喂养的大鼠补充番石榴叶粉可降低氧化应激标志物，并在实验动物中重建抗氧化酶系统。与高脂饮食喂养的大鼠相比，高脂饮食喂养的大鼠补充番石榴叶粉还显示肝脏中炎症细胞浸润和胶原蛋白沉积相对减少。本研究表明，补充番石榴叶粉可预防肥胖，改善葡萄糖耐量，并减少高碳水高脂肪饮食喂养大鼠肝脏中的炎症和氧化应激。
