Prince Md Raihan Uzzaman, Zihad S M Neamul Kabir, Ghosh Puja, Sifat Nazifa, Rouf Razina, Al Shajib Gazi Mohammad, Alam Md Ashraful, Shilpi Jamil A, Uddin Shaikh J
Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh.
University of Chinese Academy of Sciences, Beijing, China.
Front Nutr. 2021 May 10;8:653918. doi: 10.3389/fnut.2021.653918. eCollection 2021.
is a common vegetable of Bangladesh and well-known for its ethnomedicinal uses. In this study, we have evaluated the ability of powdered supplementation, methanol extract, and aqueous extract of in attenuating in high-carbohydrate-high-fat (HCHF) diet-induced obesity and associated metabolic disorders in female obese rates. Several parameters have been analyzed in this study including body weight, organ weight, fat deposition, glycemic status, lipid levels, hepatic and renal biomarkers, hepatic antioxidant status, and hepatosteatosis. All three samples of significantly reduced weight gain, organ weight, and abdominal fat deposition. Improved glucose tolerance and lipid parameters were seen in obese rats administered with powder, methanol extract, and aqueous extract. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and creatine kinase levels were normalized by the test samples. boosted hepatic antioxidant levels including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathology of liver tissue revealed increased fat infiltration and higher steatosis score in HCHF diet-fed obese rats which was brought down by . Analyzing all the results it can be concluded that this medicinal herb is beneficial in the management of obesity and obesity-induced metabolic disorders, making it a prospective food supplement.
是孟加拉国的一种常见蔬菜，以其民族药用价值而闻名。在本研究中，我们评估了粉末补充剂、甲醇提取物和水提取物减轻高碳水化合物高脂肪（HCHF）饮食诱导的肥胖及相关代谢紊乱的能力，实验对象为雌性肥胖大鼠。本研究分析了几个参数，包括体重、器官重量、脂肪沉积、血糖状态、血脂水平、肝脏和肾脏生物标志物、肝脏抗氧化状态以及肝脂肪变性。所有三种样品均显著降低了体重增加、器官重量和腹部脂肪沉积。给予粉末、甲醇提取物和水提取物的肥胖大鼠的葡萄糖耐量和脂质参数得到改善。测试样品使血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）和肌酸激酶水平恢复正常。提高了肝脏抗氧化水平，包括还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）。肝组织的组织病理学显示，HCHF饮食喂养的肥胖大鼠脂肪浸润增加，脂肪变性评分更高，而该植物提取物使其降低。分析所有结果可以得出结论，这种草药对肥胖及肥胖诱导的代谢紊乱的管理有益，使其成为一种有前景的食品补充剂。
