强直性脊柱炎患者的血清壳三糖苷酶和新蝶呤水平
Serum chitotriosidase and neopterin levels in patients with ankylosing spondylitis.
作者信息
Yavuz Ferdi, Kesikburun Bilge, Öztürk Özlem, Güzelküçük Ümüt
机构信息
Department of Physical Medicine and Rehabilitation, Health Sciences Faculty, European University of Lefke, Gemikonagi, Turkish Republic of Northern Cyprus-Mersin Fizyocare Physical Therapy Center, Alacaatlı cad. 2857 sok. No:7, 06810, Ankara, Turkey.
University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.
出版信息
Ther Adv Musculoskelet Dis. 2019 Mar 1;11:1759720X19832321. doi: 10.1177/1759720X19832321. eCollection 2019.
BACKGROUND
The aim of this study was to assess the serum chitotriosidase (ChT) and neopterin levels in patients with ankylosing spondylitis (AS) and to evaluate whether serum ChT and neopterin levels are related to disease activity.
METHODS
A total of 86 patients with AS were included in the study. Patients were divided into two groups based on Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores: The active AS patients group included 40 patients who had a BASDAI score ⩾4. The inactive AS patients group included 46 patients who had a BASDAI score <4. We compared the serum level of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ChT and neopterin between the two groups.
RESULTS
Active AS patients had significantly higher ESR, CRP, serum ChT and neopterin levels compared with the inactive AS patients group ( < 0.05). Positive correlations were found between serum ChT levels and ESR ( = 0.87, = 0.005), and CRP levels ( = 0.86, = 0.006). Also, there was a positive significant correlation between serum ChT levels and BASDAI scores ( = 0.67, = 0.03). No correlation was found between serum neopterin levels and the BASDAI scores, ESR, and CRP levels ( > 0.05). Higher disease activity (BASDAI score ⩾4) was found to be associated with ChT ( = 0.012) in the multiple logistic regression analysis.
CONCLUSION
The present study emphasized that serum ChT levels can be useful in the determination of the disease activity of AS patients.
背景
本研究旨在评估强直性脊柱炎（AS）患者的血清壳三糖苷酶（ChT）和新蝶呤水平，并评估血清ChT和新蝶呤水平是否与疾病活动度相关。
方法
本研究共纳入86例AS患者。根据巴斯强直性脊柱炎疾病活动指数（BASDAI）评分将患者分为两组：活动期AS患者组包括40例BASDAI评分≥4的患者。非活动期AS患者组包括46例BASDAI评分<4的患者。我们比较了两组患者的红细胞沉降率（ESR）、C反应蛋白（CRP）、ChT和新蝶呤的血清水平。
结果
与非活动期AS患者组相比，活动期AS患者的ESR、CRP、血清ChT和新蝶呤水平显著更高（<0.05）。血清ChT水平与ESR（=0.87，=0.005）以及CRP水平（=0.86，=0.006）之间存在正相关。此外，血清ChT水平与BASDAI评分之间也存在显著正相关（=0.67，=0.03）。血清新蝶呤水平与BASDAI评分、ESR和CRP水平之间未发现相关性（>0.05）。多因素逻辑回归分析发现，较高的疾病活动度（BASDAI评分≥4）与ChT相关（=0.012）。
结论
本研究强调血清ChT水平可用于确定AS患者的疾病活动度。
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