Stanek Agata, Romuk Ewa, Wielkoszyński Tomasz, Brożyna-Tkaczyk Klaudia, Wziątek-Kuczmik Daria, Cholewka Armand
Department and Clinic of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland.
Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Jordana 19 St., 41-808 Zabrze, Poland.
Antioxidants (Basel). 2023 Feb 19;12(2):521. doi: 10.3390/antiox12020521.
The aim of the study was to assess the effect of whole-body cryotherapy (WBC) with subsequent exercise training (WBC group) or exercise-only training (ET group) on endothelium inflammation parameters in patients with ankylosing spondylitis (AS).
The WBC procedure lasted 3 min, and exercise training consisted of one 60 min session a day, which was the same in each group. The ET group was compared to the WBC group. Endothelium (high-sensitivity C-reactive protein (hsCRP), soluble P-Selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), neopterin), and oxidative stress (lipid hydroperoxide (LHP), protein sulfhydryl (PSH), lipofuscin, paraoxonase-1(PON-1), and albumin) parameters were estimated 1 day before and 1 day after the completion of the study.
A significant decrease in hsCRP, sP-Selectin, sVCAM-1, and neopterin concentrations was observed in the WBC group after the treatment. After the treatment, in both groups, LHP and lipofuscin levels and PON-1 activity decreased significantly. The observed drop in these parameters was higher in the WBC group compared to the ET group. Albumin concentration increased in the WBC group after treatment.
Procedures of WBC have a beneficial effect on endothelium parameters in AS patients; therefore, this method can be applied in the treatment of this group of patients.
本研究旨在评估全身冷冻疗法（WBC）联合后续运动训练（WBC组）或单纯运动训练（ET组）对强直性脊柱炎（AS）患者内皮炎症参数的影响。
WBC疗程持续3分钟，运动训练包括每天一次60分钟的训练，每组训练内容相同。将ET组与WBC组进行比较。在研究开始前1天和结束后1天评估内皮（高敏C反应蛋白（hsCRP）、可溶性P选择素、可溶性血管细胞黏附分子-1（sVCAM-1）、新蝶呤）和氧化应激（脂质过氧化氢（LHP）、蛋白质巯基（PSH）、脂褐素、对氧磷酶-1（PON-1）和白蛋白）参数。
治疗后，WBC组hsCRP、sP选择素、sVCAM-1和新蝶呤浓度显著降低。治疗后，两组的LHP和脂褐素水平以及PON-1活性均显著下降。与ET组相比，WBC组这些参数的下降更为明显。治疗后WBC组白蛋白浓度升高。
WBC程序对AS患者的内皮参数有有益影响；因此，该方法可应用于这组患者的治疗。
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