Zhong Weixia, Darmani Nissar A
Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766.
Rem Open Access. 2017;2. Epub 2017 Oct 31.
Nausea and vomiting are often considered as stressful symptoms of many diseases and drugs. In fact they are the most feared and debilitating side-effects of many cancer chemotherapeutics and the main cause of patient noncompliance. Despite years of substantial research, the intracellular emetic signals are at best poorly understood or remain unknown. Among different receptor-mediated emetic signaling cascades, one potential converging signal appears to be changes in the cytosolic concentration of Ca. In this editorial, we focus on Ca-related intracellular signals underlying emesis mediated by various emetogens. This strategy will help us understand common signaling mechanisms downstream of diverse emetogens and should therefore promote development of new antiemetics for the treatment nausea and vomiting caused by diverse diseases, drugs, as well as viruses and bacterial infections.
恶心和呕吐常被视为许多疾病及药物的应激症状。事实上，它们是许多癌症化疗药物最令人恐惧且使人虚弱的副作用，也是患者不依从治疗的主要原因。尽管经过多年大量研究，但细胞内催吐信号至多只是了解甚少或仍不为人知。在不同的受体介导的催吐信号级联反应中，一个潜在的汇聚信号似乎是胞质钙浓度的变化。在这篇社论中，我们聚焦于由各种催吐原介导的呕吐所涉及的与钙相关的细胞内信号。这一策略将有助于我们理解不同催吐原下游的共同信号机制，因此应该会促进新型止吐药的研发，用于治疗由各种疾病、药物以及病毒和细菌感染引起的恶心和呕吐。
