Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Department of Physical Medicine and Rehabilitation, New York Presbyterian Hospital, Weill Cornell Medical College/Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Curr Pain Headache Rep. 2019 Mar 11;23(3):20. doi: 10.1007/s11916-019-0758-0.
Regenerative modalities have been identified in numerous clinical studies as beneficial in various settings. The focus of this review is to summarize key studies and current concepts for the role of regenerative medicine in the treatment of neuraxial back pain.
Recent studies have demonstrated the benefit of regenerative therapies for the treatment of neuraxial back pain. A literature review of clinical trials published between 2015 and 2017 was performed using OVID, PubMed, and Google Scholar to identify investigations attempting to determine the efficacy of various regenerative modalities on two primary sources of low back pain: facet arthropathy and degenerative disc disease. The seven articles analyzed in this systematic review present promising data regarding the use of these autologous biologic treatments, but many of these investigations have several limitations in common including small sample size. Regenerative medicine has been shown to demonstrate efficacy in the treatment of neuraxial back pain. As the field advances, new studies are needed comparing efficacy and safety profiles to better determine best practice techniques and standards in the future.
在许多临床研究中，已经确定了多种再生方式在各种情况下都是有益的。本综述的重点是总结再生医学在治疗脊柱源性背痛中的关键研究和当前概念。
最近的研究表明，再生疗法对治疗脊柱源性背痛有益。使用 OVID、PubMed 和 Google Scholar 对 2015 年至 2017 年期间发表的临床试验进行文献回顾，以确定试图确定各种再生方式对两种主要来源的腰痛的疗效的研究：小关节病和退行性椎间盘疾病。本系统评价分析的七篇文章提供了关于使用这些自体生物治疗的有希望的数据，但这些研究中有许多共同的局限性，包括样本量小。再生医学已被证明在治疗脊柱源性背痛方面有效。随着该领域的发展，需要进行新的研究来比较疗效和安全性，以更好地确定未来的最佳实践技术和标准。
