The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
Tetranov Biopharm LLC and Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou 450052 , People's Republic of China.
J Org Chem. 2019 Apr 5;84(7):4040-4049. doi: 10.1021/acs.joc.9b00035. Epub 2019 Mar 19.
A novel oxidation of benzylic C-H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.
发展了一种新颖的苄位 C-H 键氧化反应，用于合成各种六元 N-杂芳基醛酮。该方法具有操作简单、反应条件温和、无需使用有毒试剂和过渡金属等明显优点。本方法应为 N-杂环的合成和修饰提供了一种有用的途径。
