Reproductive Department, Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Curr Mol Med. 2019;19(1):54-75. doi: 10.2174/1566524019666190308163315.
The relationship between OCT4 and clinicopathological features in lung cancer is shown to be controversial in recent publications. Therefore, we conducted this meta-analysis to quantitatively investigate the prognostic and clinicopathological characteristics of OCT4 in lung cancer.
A comprehensive literature search of the PubMed, EMBASE, Cochrane Library, WOS, CNKI and Wanfang databases was performed to identify studies. Correlations between OCT4 expression and survival outcomes or clinicopathological features were analyzed using meta-analysis methods.
Twenty-one studies with 2523 patients were included. High OCT4 expression showed a poorer overall survival (OS) (univariate: HR= 2.00, 95% CI = (1.68, 2.39), p<0.0001; multivariate: HR= 2.43, 95% CI = (1.67, 3.55), p<0.0001) and median overall survival (MSR = 0.51, 95% CI = (0.44, 0.58), p < 0.0001), disease-free survival (DFS) (HR= 2.18, 95% CI = (1.30, 3.67), p = 0.003) and poorer disease-specific survival (DSS) (HR= 2.23, 95% CI = (1.21, 4.11), p = 0.010). Furthermore, high OCT4 expression was found to be related with lower 5 year disease-specific survival rate (OR= 0.24, 95% CI = (0.14, 0.41), p<0.0001) and 10 year overall survival rate (OR= 0.22, 95% CI = (0.12, 0.40), p=0.0001). Additionally, OCT4-high expression was also strongly associated with higher clinical TNM stage, lymph node metastasis, tumor distant metastasis, higher histopathologic grade, but not related with gender, smoking status, tumor size and histologic type of lung cancer.
OCT4 over-expression in lung cancer was strongly related to poorer clinicopathological features and worse survival outcomes, which suggests that OCT4 could be a valuable prognostic marker in lung cancer.
最近的出版物表明，OCT4 与肺癌的临床病理特征之间的关系存在争议。因此，我们进行了这项荟萃分析，以定量研究 OCT4 在肺癌中的预后和临床病理特征。
对 PubMed、EMBASE、Cochrane 图书馆、WOS、CNKI 和万方数据库进行全面文献检索，以确定研究。使用荟萃分析方法分析 OCT4 表达与生存结局或临床病理特征之间的相关性。
纳入 21 项研究，共 2523 例患者。OCT4 高表达与总生存期（OS）较差相关（单因素：HR=2.00，95%CI=（1.68，2.39），p<0.0001；多因素：HR=2.43，95%CI=（1.67，3.55），p<0.0001）和中位总生存期（MSR=0.51，95%CI=（0.44，0.58），p<0.0001），无病生存期（DFS）（HR=2.18，95%CI=（1.30，3.67），p=0.003）和较差的疾病特异性生存率（DSS）（HR=2.23，95%CI=（1.21，4.11），p=0.010）。此外，高 OCT4 表达与较低的 5 年疾病特异性生存率（OR=0.24，95%CI=（0.14，0.41），p<0.0001）和 10 年总生存率（OR=0.22，95%CI=（0.12，0.40），p=0.0001）相关。此外，OCT4 高表达还与较高的临床 TNM 分期、淋巴结转移、远处转移、较高的组织病理学分级密切相关，但与性别、吸烟状况、肿瘤大小和肺癌组织学类型无关。
肺癌中 OCT4 的过度表达与较差的临床病理特征和生存结局密切相关，这表明 OCT4 可能是肺癌有价值的预后标志物。
