促性腺激素释放激素、达那唑和前列腺素阻断与兔卵巢过度刺激综合征的卵巢肿大及腹水形成的关系。

Relationship of gonadotropin-releasing hormone, danazol, and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit.

作者信息

Pride S M, Yuen B H, Moon Y S, Leung P C

出版信息

Am J Obstet Gynecol. 1986 May;154(5):1155-60. doi: 10.1016/0002-9378(86)90778-7.

Abstract

The effects of pharmacologic doses of gonadotropin-releasing hormone, danazol, and indomethacin on the clinical and endocrinologic features of the ovarian hyperstimulation syndrome were studied in the rabbit. The ovarian hyperstimulation syndrome was induced with Pergonal (75 IU of follicle-stimulating hormone and 75 IU of luteinizing hormone) and a follicle-stimulating hormone-dominant gonadotropin preparation (85 IU of follicle-stimulating hormone and 53 IU of luteinizing hormone). None of the three agents tested were effective in suppressing the ovarian enlargement and ascites formation in these animals. Ascites developed despite quite significant variations in plasma and intraovarian sex steroid hormone and intraovarian prostaglandin F levels induced by danazol and indomethacin. Ascites develops in hyperstimulated women in association with both follicular and luteal hyperstimulation. In contrast, the ascites response in the hyperstimulated rabbit develops in the presence of follicular hyperstimulation alone without a significant degree of luteal hyperstimulation.

摘要

在兔子身上研究了药理剂量的促性腺激素释放激素、达那唑和吲哚美辛对卵巢过度刺激综合征临床和内分泌特征的影响。用 Pergonal（75 国际单位促卵泡激素和 75 国际单位促黄体生成素）和一种以促卵泡激素为主的促性腺激素制剂（85 国际单位促卵泡激素和 53 国际单位促黄体生成素）诱发卵巢过度刺激综合征。所测试的三种药物均未能有效抑制这些动物的卵巢肿大和腹水形成。尽管达那唑和吲哚美辛引起血浆和卵巢内性甾体激素以及卵巢内前列腺素 F 水平有相当大的变化，但腹水仍会出现。在过度刺激的女性中，腹水的出现与卵泡期和黄体期的过度刺激均有关。相比之下，过度刺激的兔子中的腹水反应仅在卵泡期过度刺激的情况下出现，而黄体期没有明显的过度刺激。