Antitumor activity on human bladder cancer T-24 cells and composition analysis of the core of fruit.

In this study, antitumor activity and composition analysis of the core of fruit were investigated. The cores were extracted by 80% ethanol to obtain the crude extract (), which was successively distributed by different concentrations of ethanol with MCI resin to obtain three different parts ( to ). Cytotoxicity activities showed that , , and exhibited good inhibition against T-24 with IC values of 6.7 ± 1.3, 6.9 ± 0.9, and 6.7 ± 1.7 μg/mL, respectively. has a strong inhibitory activity on T-24 cells, mainly due to effectively increasing the release of intracellular calcium ions and reactive oxygen species. In addition, can inhibit T-24 cells migration and invasion. Further composition analysis on was detected by LC-Q-TOFMS implying the main components to be ellagic acid and its derivatives.