评估左炔诺孕酮及其光产物的内分泌干扰效应：光催化去除后释放部分的环境影响。
Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal.
机构信息
Grupo de Investigación Ingeniar, Facultad de Ciencias Básicas e Ingeniería, Corporación Universitaria Remington, Calle 51 No. 51-27, Medellín, Colombia.
College of Engineering, Cornell University, USA.
出版信息
J Hazard Mater. 2019 Jun 5;371:273-279. doi: 10.1016/j.jhazmat.2019.02.095. Epub 2019 Feb 27.
The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatment plants, and many species may be exposed to low traces of this compound from discharged effluents. Thus, in this study, a photocatalytic process for removing LNG along with screening of endocrine disruptor effects for risk assessment was applied. Although the removal rate of LNG by ultraviolet C (UV-C) radiation was >90%, reproductive toxicity testing using the BeWo cell line exposed to LNG and its degraded fraction showed the reduced production of basal human chorionic gonadotropin hormone (β-hCG) by more than 73%, from 8.90 mIU mL to <2.39 mIU mL, with both LNG and the degraded fraction. β-hCG hormone has been implicated in the viability of trophoblastic cells during the first trimester of pregnancy; therefore, degraded fractions and waterborne LNG may affect reproduction in some aquatic species and humans with low level of exposure.
据报道，通过直接排放和人类排泄，左炔诺孕酮（LNG）已经存在于水体中，但它对水生物种和人类生殖的影响仍不清楚。由于其难降解的特性，LNG 在废水处理厂中不能被完全去除，许多物种可能会从排放的废水中接触到低浓度的这种化合物。因此，在本研究中，应用了一种光催化工艺来去除 LNG 并筛选内分泌干扰物的风险评估效应。虽然紫外线 C（UV-C）辐射对 LNG 的去除率>90%，但用 BeWo 细胞系进行的生殖毒性测试显示，暴露于 LNG 及其降解产物的情况下，基础人绒毛膜促性腺激素（β-hCG）的产生减少了超过 73%，从 8.90 mIU mL 降至<2.39 mIU mL，LNG 和降解产物都是如此。β-hCG 激素与妊娠早期滋养层细胞的活力有关；因此，降解产物和水传播的 LNG 可能会对一些水生物种和低暴露水平的人类的生殖产生影响。
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