氯氮平引起的粒细胞缺乏症和白细胞减少症：在泰国精神科门诊服务中的发生率、相关因素和血液学不良反应监测率。
Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand.
机构信息
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Nakorn Ratchasima Rajanagarindra Psychiatric Hospital, Nakorn Ratchasima, Thailand.
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
Asian J Psychiatr. 2019 Mar;41:13-16. doi: 10.1016/j.ajp.2019.03.002. Epub 2019 Mar 5.
The present study aimed to investigate the incidence of agranulocytosis and leukopenia and its associated factors in Thai schizophrenia patients treated with clozapine and the rate of hematologic adverse events monitored in clinical practice. Data were collected from the medical records of 641 outpatients at two hospitals. The results showed no cases of agranulocytosis and 20 cases of leukopenia (3.1%), 85% of which were observed after 1 year of prescription. The associated factors were female (p = 0.019) and duration of clozapine prescription (p = 0.026). According to the guideline for safety monitoring, 23.6% of cases had neutrophils count monitoring.
本研究旨在调查泰国精神分裂症患者使用氯氮平治疗后发生粒细胞缺乏症和白细胞减少症的发生率及其相关因素，以及临床实践中监测血液学不良事件的发生率。数据来自两家医院 641 名门诊患者的病历。结果显示，无粒细胞缺乏症病例，白细胞减少症（3.1%）20 例，其中 85%在处方 1 年后观察到。相关因素为女性（p=0.019）和氯氮平处方持续时间（p=0.026）。根据安全监测指南，23.6%的病例进行了中性粒细胞计数监测。
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