College of Plant Protection, China Agricultural University, Beijing, China.
College of Plant Protection, China Agricultural University, Beijing, China.
Colloids Surf B Biointerfaces. 2019 Jun 1;178:153-162. doi: 10.1016/j.colsurfb.2019.03.009. Epub 2019 Mar 6.
Based on the specific binding between the receptors and ligands, novel targeted nanocapsules were prepared by using silica covalently bonded with dopamine to increase the insecticidal efficacy of λ-cyhalothrin. The targeted release mechanism of λ-cyhalothrin nanocapsules (NC) nanocapsules was verified by enzymatic analysis, fluorescent marking method and high performance liquid chromatograph. The results showed NC had uniform particle size (800 nm) and approximately 31% (w/w) loading efficiency of λ-cyhalothrin. The stability of λ-cyhalothrin in nanocapsuels was improved under different pH and temperature conditions. The NC showed sustainable release properties and the release kinetics mainly belonged to Fickian diffusion at all experimental conditions. Compared to λ-cyhalothrin emulsifiable concentrate and microcapsule suspension, the NC exhibited more excellent insecticidal activity. The micronucleus test indicated that NC significantly reduced the genotoxicity of λ-cyhalothrin to non-target organisms. This work offers a novel and efficient way to use targeted drug delivery system to improve the insecticidal activity, and may be extended to other pesticides in the future.
基于受体和配体之间的特异性结合，使用与多巴胺共价结合的二氧化硅制备了新型靶向纳米胶囊，以提高氯氟氰菊酯的杀虫功效。通过酶分析、荧光标记法和高效液相色谱法验证了氯氟氰菊酯纳米胶囊（NC）纳米胶囊的靶向释放机制。结果表明，NC 具有均匀的粒径（800nm）和约 31%（w/w）的氯氟氰菊酯载药量。在不同 pH 和温度条件下，纳米胶囊中氯氟氰菊酯的稳定性得到提高。NC 表现出持续释放的特性，在所有实验条件下，释放动力学主要属于菲克扩散。与氯氟氰菊酯乳油和微胶囊悬浮剂相比，NC 表现出更优异的杀虫活性。微核试验表明，NC 显著降低了氯氟氰菊酯对非靶标生物的遗传毒性。这项工作提供了一种使用靶向药物传递系统来提高杀虫活性的新方法，未来可能会扩展到其他农药。
