Beamer W G, Tennent B J
Biol Reprod. 1986 May;34(4):761-70. doi: 10.1095/biolreprod34.4.761.
Genetic and irradiation models of ovarian tumorigenesis were investigated for evidence that elevated gonadotropins have a role in tumorigenesis. Wx/Wv mice lack oocytes at birth, develop complex mesothelial adenomas by 6 mo, and additional ovarian tumor types later. Uptake of iodinated human chorionic gonadotropin (125I-hCG) was measured in mice aged 1 to 30 mo, and uptake iodinated human follicle-stimulating hormone (125I-hFSH) was measured in mice aged 1 to 12 mo. Gonadotropin uptake by Wx/Wv ovaries in vivo declined quickly and was undetectable by 6 mo. Irradiated ovaries rapidly lost oocytes and follicular structures, formed mesothelial adenomas by 5 mo, and later formed additional types of ovarian tumors. In the irradiation model, 125I-hCG uptake also declined quickly and was undetectable by 3 mo of age. Neither the surface nor the tubular epithelium of the mesothelial adenoma were consistently labeled by 125I-hCG in autoradiography studies with either model. Although these data do not exclude an acute role for gonadotropins in initiation of preneoplastic events, they do indicate that ovarian cells do not require chronic gonadotropin stimulation during subsequent tumorigenesis. These findings are discussed in relation to additional models of ovarian tumorigenesis.
研究了卵巢肿瘤发生的遗传和辐射模型，以寻找促性腺激素升高在肿瘤发生中起作用的证据。Wx/Wv小鼠出生时缺乏卵母细胞，6个月时会发展出复杂的间皮腺瘤，之后还会出现其他类型的卵巢肿瘤。在1至30个月大的小鼠中测量了碘化人绒毛膜促性腺激素（125I-hCG）的摄取量，并在1至12个月大的小鼠中测量了碘化人促卵泡激素（125I-hFSH）的摄取量。Wx/Wv卵巢在体内对促性腺激素的摄取迅速下降，到6个月时无法检测到。接受辐射的卵巢迅速失去卵母细胞和卵泡结构，5个月时形成间皮腺瘤，之后还会形成其他类型的卵巢肿瘤。在辐射模型中，125I-hCG的摄取也迅速下降，到3个月大时无法检测到。在这两种模型的放射自显影研究中，间皮腺瘤的表面上皮和管状上皮均未被125I-hCG持续标记。尽管这些数据不排除促性腺激素在肿瘤前事件启动中的急性作用，但它们确实表明卵巢细胞在随后的肿瘤发生过程中不需要慢性促性腺激素刺激。结合卵巢肿瘤发生的其他模型对这些发现进行了讨论。
