Mulac Hospital, Newborn Department, Pilsen, Czech Republic.
Department of Clinical Chemistry and Hematology, Mulac Hospital, Pilsen, Czech Republic.
Ital J Pediatr. 2019 Mar 11;45(1):35. doi: 10.1186/s13052-019-0620-3.
The benefit of probiotics in newborn children in relation to allergy and general morbidity later in life appears to be controversial. Allergic diseases represent an increasingly important health problem worldwide in recent years. This is evident in all age groups. The occurrence of allergic illnesses also continues to rise exponentially, and thus the use of preventive and prognostic methods, particularly in children with an inherently higher risk of allergy, is gaining increased importance. Since the advent of probiotics the effect of probiosis on immunity through alterations of composition and function of the human gut microbiome has been increasingly studied. The exact mechanisms have not yet been clearly defined. The Academy of Sciences of the Czech Republic (The Czech Academy of Sciences has suggested that the expression of TH1 and TH2 cytokines in umbilical blood is associated with an increased risk of allergies. The counter -balance of Th1 and Th2 affect Immunoglobulin E (IgE) production and maturation of the gastrointestinal tract epithelium.
We examined IgE levels in 3000 samples of umbilical blood taken from children born into families with a positive history of allergy in one or both parents from 2007 to 2017. At the age of ten days, those with high IgE were given Colinfant Newborn (a lyophilized non-pathogenic strain of Escherichia.coli) for one month, three times weekly. At 15 months and three years we investigated the levels of Immunoglobulins E,A and G, and the incidence of illness and allergy. The results revealed that allergy and high umbilical IgE is strongly linked with family history (p ≤ 0.001). We also detected differences in seasonality, especially with regards to pollen allergies. Eighty percent of children treated with Colinfant Newborn had significantly reduced IgE and morbidity at 13-15 months and 3 years, and furthermore without any clinical signs of allergy. Normalization of Immunoglobulins A and G was seen in 90% of treated subjects (p ≤ 0.001). These levels significantly correlated with an almost negligible morbidity up to 4 years of life. Colinfant Newborn, a lyophilized strain of Esherichia coli (E. coli), and a normal component of intestinal flora, readily colonizes the intestinal tract. It's long term presence significantly stimulates the production of specific and non-specific intestinal antibodies. and optimalizes immune development through tolerance. In our study Colinfant Newborn reduced the incidence of infections later in life by safely and effectively normalizing immunoglobulin levels in the majority of treated patients.
Our study strongly suggests as positive effect of physiological Escherichia coli on the microbiome of newborn children as evidenced by a significantly reduced incidence of allergy and morbidity when applied early in life. These benefits appear to be strongly strain specific.
益生菌对新生儿的益处与日后的过敏和一般发病率之间的关系似乎存在争议。过敏疾病是近年来全球范围内日益重要的健康问题。所有年龄段都有这种情况。过敏疾病的发生也呈指数级增长,因此,使用预防和预后方法,特别是对具有更高过敏风险的儿童,越来越重要。自从益生菌问世以来,通过改变人体肠道微生物组的组成和功能来影响免疫的益生菌作用已经越来越受到研究。确切的机制尚未明确界定。捷克科学院(捷克科学院已表明,脐血中 TH1 和 TH2 细胞因子的表达与过敏风险增加有关。Th1 和 Th2 的平衡会影响免疫球蛋白 E(IgE)的产生和胃肠道上皮的成熟。
我们检查了 2007 年至 2017 年期间从父母一方或双方均有过敏病史的家庭中出生的 3000 名儿童的脐血中 IgE 水平。在出生后 10 天,那些 IgE 水平高的婴儿给予了科林婴儿(一种冻干的非致病性大肠杆菌),一个月内每周三次。在 15 个月和 3 岁时,我们调查了免疫球蛋白 E、A 和 G 的水平,以及疾病和过敏的发生率。结果表明,过敏和高脐 IgE 与家族史密切相关(p≤0.001)。我们还检测到季节性差异,尤其是花粉过敏。80%接受科林婴儿治疗的儿童在 13-15 个月和 3 岁时 IgE 和发病率显著降低,并且没有任何过敏迹象。在治疗的受试者中,90%的人观察到免疫球蛋白 A 和 G 正常化(p≤0.001)。这些水平与 4 岁以下的低发病率显著相关。科林婴儿是一种冻干的大肠杆菌(大肠杆菌)菌株,是肠道菌群的正常组成部分,很容易在肠道中定植。它的长期存在通过耐受显著刺激肠道特异性和非特异性抗体的产生,并优化免疫发育。在我们的研究中,科林婴儿通过安全有效地使大多数接受治疗的患者的免疫球蛋白水平正常化,从而降低了生命后期感染的发生率。这些益处似乎与菌株特异性密切相关。
我们的研究强烈表明,生理大肠杆菌对新生儿微生物组的积极影响,因为早期应用可显著降低过敏和发病率。这些好处似乎与菌株特异性密切相关。