孕期母亲使用益生菌及其对未经过筛选人群中后代健康的影响。
Maternal use of probiotics during pregnancy and effects on their offspring's health in an unselected population.
作者信息
Rutten Nicole, Van der Gugten Anne, Uiterwaal Cuno, Vlieger Arine, Rijkers Ger, Van der Ent Kors
机构信息
Department of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Room KH.01.419.0, PO Box 85090, Utrecht, 3508 AB, The Netherlands.
Department of Pediatrics, St. Antonius Hospital, PO Box 2500, Nieuwegein, 3430 EM, The Netherlands.
出版信息
Eur J Pediatr. 2016 Feb;175(2):229-35. doi: 10.1007/s00431-015-2618-1. Epub 2015 Aug 30.
UNLABELLED
Probiotics are used by women in the perinatal period and may improve balance of microbiota, with possible health benefits for both mother and baby. Characteristics and (health) behaviour patterns of mothers using probiotics during pregnancy, and health effects on their offspring, were investigated. Differences between mothers using probiotics during pregnancy and those who did not, were assessed. In total, 341 out of 2491 (13.7%) mothers reported use of probiotics during pregnancy. There were no significant differences in maternal features (gestation, age, ethnicity, education) between users and non-users. Logistic regression analyses showed that consumption of probiotics was significantly associated with use of homeopathic products [odds ratio (OR) 1.65, 95% confidence interval (CI) 1.17-2.33, p = 0.005], maternal history of smoking (OR 1.72, 95% CI 1.25-2.37, p = 0.001) and paternal history of smoking (OR 1.39, 95% CI 1.01-1.89, p = 0.05). Common disease symptoms during the first year of life in the offspring did not differ between both groups.
CONCLUSION
The use of probiotics or other health-related products without doctor's prescription during pregnancy might point to compensation for types of less favourable behaviour. Probiotic use during pregnancy does not seem to induce positive health effects in the offspring in an unselected population.
WHAT IS KNOWN
Aberrant microbiota compositions have been detected during critical periods when early programming occurs including pregnancy and early neonatal life. Probiotics modulate intestinal microbiota composition and are associated with positive health effects.
WHAT IS NEW
The use of probiotics or other health-related products without doctor's prescription during pregnancy is associated with and might point to compensation for types of less favourable behaviour. Probiotic use during pregnancy does not induce positive health effects in the offspring in this unselected population.
未标注
围产期女性会使用益生菌，这可能改善微生物群平衡，对母婴健康可能有益。本研究调查了孕期使用益生菌的母亲的特征和（健康）行为模式，以及对其后代的健康影响。评估了孕期使用益生菌的母亲与未使用益生菌的母亲之间的差异。在2491名母亲中，共有341名（13.7%）报告在孕期使用了益生菌。使用者和非使用者在母亲特征（孕周、年龄、种族、教育程度）方面无显著差异。逻辑回归分析表明，益生菌的使用与顺势疗法产品的使用显著相关[比值比（OR）1.65，95%置信区间（CI）1.17 - 2.33，p = 0.005]、母亲吸烟史（OR 1.72，95% CI 1.25 - 2.37，p = 0.001）和父亲吸烟史（OR 1.39，95% CI 1.01 - 1.89，p = 0.05）。两组后代在出生后第一年的常见疾病症状无差异。
结论
孕期在无医生处方的情况下使用益生菌或其他与健康相关的产品，可能表明是对不良行为类型的一种补偿。在未经过挑选的人群中，孕期使用益生菌似乎不会对后代产生积极的健康影响。
已知信息
在包括孕期和新生儿早期生命等早期编程的关键时期，已检测到微生物群组成异常。益生菌可调节肠道微生物群组成，并与积极的健康影响相关。
新发现
孕期在无医生处方的情况下使用益生菌或其他与健康相关的产品，与不良行为类型有关，可能是对其的一种补偿。在这个未经过挑选的人群中，孕期使用益生菌不会对后代产生积极的健康影响。
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