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抗血小板治疗在轻度创伤性脑损伤后颅内出血发生中的作用。

Role of antiplatelet therapy in the development of intracranial bleeding after mild traumatic brain injury.

作者信息

Genebat González Miguel, Dusseck Brutus Reginald, García-Olloqui Ángel, García-Delgado Rosado Horacio, Bellido Alba Rafael, Pérez Torres Ignacio

机构信息

Servicio de Urgencias, Hospital Universitario Virgen del Rocío, Sevilla, España.

Unidad de Cuidados Intensivos, Hospital Universitario Virgen del Rocío, Sevilla, España.

出版信息

Med Clin (Barc). 2020 Jan 24;154(2):52-54. doi: 10.1016/j.medcli.2019.01.011. Epub 2019 Mar 8.

DOI:10.1016/j.medcli.2019.01.011
PMID:30857793
Abstract

INTRODUCTION AND OBJECTIVE

The use of antiplatelet agents is increasing, mainly in elderly patients in whom cranial trauma is a frequent reason for consultation to the emergency department. In this context, discordances have been described regarding the increased risk of post-traumatic injury that involves taking antiplatelet drugs. Therefore, the objective of this present study was to analyse factors associated with intracranial bleeding after mild brain trauma.

PATIENTS AND METHODS

A retrospective study was designed that included all patients who had consulted the emergency department during 2016 because of mild brain trauma (Glasgow coma scale 14-15) and excluded patients under anticoagulant therapy. A logistic regression analysis was performed to analyse the variables associated with intracranial bleeding.

RESULTS

566 patients were included in the study. 18% of them were taking antiplatelet drugs. Tomography showed haemorrhagic intracranial damage in 16.1%. Factors associated with intracranial bleeding were: advanced age, Glasgow coma scale < 15, high-energy trauma and antiplatelet therapy.

DISCUSSION

Antiplatelet therapy emerges as a risk factor for intracranial bleeding after mild head trauma, in addition to other known factors.

摘要

引言与目的

抗血小板药物的使用正在增加,主要用于老年患者,在这些患者中,颅脑外伤是他们频繁前往急诊科就诊的原因。在这种情况下,关于服用抗血小板药物导致创伤后损伤风险增加存在不一致的描述。因此,本研究的目的是分析轻度脑外伤后颅内出血的相关因素。

患者与方法

设计了一项回顾性研究,纳入了2016年因轻度脑外伤(格拉斯哥昏迷量表评分为14 - 15分)前往急诊科就诊的所有患者,并排除了接受抗凝治疗的患者。进行逻辑回归分析以分析与颅内出血相关的变量。

结果

566例患者纳入研究。其中18%正在服用抗血小板药物。断层扫描显示16.1%的患者存在颅内出血性损伤。与颅内出血相关的因素有:高龄、格拉斯哥昏迷量表评分<15分、高能创伤和抗血小板治疗。

讨论

除其他已知因素外,抗血小板治疗是轻度头部外伤后颅内出血的一个危险因素。

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