Vos P H, Pauwels E K, Vossepoel A M
Cardiovasc Intervent Radiol. 1986;9(1):7-12. doi: 10.1007/BF02576974.
Experimental studies have been made of lesion detectability in myocardial perfusion studies using thallium-201. A series of images (AP view) was generated mathematically. Images were simulated with 100k, 200k, and 300k counts for the complete image and either non- or half-perfused lesions (lesion volume 1-6 1/2% of total myocardial volume). In addition thallium images were generated excluding scatter; images were also generated with a radiopharmaceutical using 140, 184 and 296 keV, assuming the biological distribution of thallium. All images were interpreted by seven observers. Count density did not affect the true-positive fraction of the interpretations. However, the false-positive fraction decreased significantly when count density increased. Lesions located far from the camera were detected worst. The intraobserved variability was largest for interpretation of these regions. Small lesions were poorly detected. Perfusion of lesions significantly affected their detection, independent of the count density, lesion volume, and lesion location. Scatter did not affect the detection of lesions. No significant difference was found when the performance of the observers was compared for 80 keV and 140 keV. The use of 184-keV and 296-keV photons resulted in a lower detection rate probably because of the use of a high energy collimator.
已经使用铊 - 201对心肌灌注研究中的病变可检测性进行了实验研究。通过数学方法生成了一系列图像（前后位视图）。用100k、200k和300k计数对完整图像以及非灌注或半灌注病变（病变体积占全心肌体积的1 - 6.5%）进行图像模拟。此外，生成了排除散射的铊图像；还使用放射性药物，假设铊的生物分布，生成了能量为140、184和296keV的图像。所有图像由七位观察者进行解读。计数密度不影响解读的真阳性率。然而，当计数密度增加时，假阳性率显著降低。远离相机的病变检测效果最差。这些区域解读的观察者内变异性最大。小病变检测效果不佳。病变的灌注情况对其检测有显著影响，与计数密度、病变体积和病变位置无关。散射不影响病变的检测。比较观察者对80keV和140keV的表现时未发现显著差异。使用184keV和296keV光子导致检测率较低，可能是因为使用了高能准直器。
