早产儿血小板输注阈值（PlaNeT-2试验）
Platelet transfusion thresholds in premature neonates (PlaNeT-2 trial).
作者信息
Estcourt L J
机构信息
NHS Blood and Transplant, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, Oxford, UK.
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
出版信息
Transfus Med. 2019 Feb;29(1):20-22. doi: 10.1111/tme.12587.
CLINICAL QUESTION
Does transfusing platelets to preterm infants (< 34 weeks) at a higher platelet count threshold count (< 50 x 10 /L) reduce the risk of major bleeding or death compared to only transfusing platelets when the platelet count drops below 25 x 10 /L.
EVIDENCE FROM TRIAL
Preterm infants with a low platelet count who were transfused platelets at the higher platelet count threshold had a higher risk of dying or having a major bleed than those who were not. The reasons why this occurred are currently unclear.
临床问题
与仅在血小板计数降至25×10⁹/L以下时输注血小板相比，在较高血小板计数阈值（<50×10⁹/L）时给早产儿（<34周）输注血小板是否能降低大出血或死亡风险？
试验证据
血小板计数低的早产儿在较高血小板计数阈值时输注血小板，其死亡或发生大出血的风险高于未输注血小板的早产儿。目前尚不清楚出现这种情况的原因。
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