Dimopoulos Konstantinos, Grønbaek Kirsten
Department of Hematology, Rigshospitalet, University Hospital Copenhagen, Copenhagen, Denmark.
Biotech Research and Innovation Centre (BRIC) Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
APMIS. 2019 May;127(5):316-328. doi: 10.1111/apm.12906. Epub 2019 Mar 12.
The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also epigenetic abnormalities in cancer cells. The extensive exploration of the cancer epigenome has provided insights into key pathways involved in tumorigenesis, as well as has allowed the development of novel epigenetic therapies. In this review, we will present the important role of epigenetic alterations in hematological diseases, with special focus on epigenetically-based targeting of hematological malignancies.
在过去几十年里，人们对癌症生物学的认识不断深入，这凸显了癌细胞中不仅基因畸变，而且表观遗传异常的重要性。对癌症表观基因组的广泛探索，不仅为肿瘤发生所涉及的关键途径提供了见解，还推动了新型表观遗传疗法的发展。在本综述中，我们将阐述表观遗传改变在血液系统疾病中的重要作用，特别关注基于表观遗传学对血液系统恶性肿瘤的靶向治疗。
