Wakabayashi I, Shibasaki T, Ling N
Clin Endocrinol (Oxf). 1986 Mar;24(3):279-83. doi: 10.1111/j.1365-2265.1986.tb03268.x.
The capability of the anterior pituitary gland to secrete GH in response to an intravenous injection of growth hormone-releasing factor (GRF) and insulin-induced hypoglycaemia was evaluated in 9 healthy male subjects ranging in age between 37 and 52 years old. Plasma GH response to 100 micrograms human GRF showed considerable intersubject variation and the increment of the peak value from the basal did not exceed 5 ng/ml in four out of 9 subjects. In contrast, insulin-induced hypoglycaemia resulted in a consistent stimulation of GH that exceeded 21 ng/ml in all subjects. The mean peak GH response after insulin-induced hypoglycaemia was significantly higher than that after GRF (27.4 +/- 1.6 vs 10.6 +/- 1.9 ng/ml). These results demonstrate that a significant divergence exists in plasma GH responses between the two provocative tests in the middle-aged subjects and suggest that the stimulation of GH following insulin-induced hypoglycaemia is not mediated solely by endogenous GRF.
对9名年龄在37至52岁之间的健康男性受试者，评估了垂体前叶在静脉注射生长激素释放因子（GRF）和胰岛素诱导低血糖反应下分泌生长激素（GH）的能力。血浆GH对100微克人GRF的反应在受试者间存在显著差异，9名受试者中有4名从基础值到峰值的增加值未超过5纳克/毫升。相比之下，胰岛素诱导的低血糖导致所有受试者的GH持续刺激，超过21纳克/毫升。胰岛素诱导低血糖后GH的平均峰值反应显著高于GRF后（27.4±1.6对10.6±1.9纳克/毫升）。这些结果表明，中年受试者在这两种激发试验之间的血浆GH反应存在显著差异，并提示胰岛素诱导低血糖后GH的刺激并非仅由内源性GRF介导。
