Ali Maisa, Shaukat Adila, Al-Suwaidi Zubaida, Al-Maslamani Muna
Department of Medicine, Division of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar.
National TB Lab, HMC, Doha, Qatar.
Int J Mycobacteriol. 2019 Jan-Mar;8(1):101-103. doi: 10.4103/ijmy.ijmy_147_18.
Despite the high prevalence of tuberculosis (TB) in developing countries, primary pancreatic TB is a rare entity. We present a case of pancreatic TB in an immunocompetent patient who was found to have pancreatic mass resembling malignancy. A 40-year-old Indian male presented to the medical emergency room with complaints of abdominal pain and fever for 2 weeks' duration. He had a history of unintentional weight loss of about 20 pounds in the past 2 months. There was no significant history of exposure to TB patient. Family history was unremarkable for any malignancy. On examination, the significant finding was epigastric tenderness. He was thoroughly investigated, his purified protein derivative and QuantiFERON were negative. Chest X-ray was unremarkable. Computed tomography scan abdomen was performed that revealed large heterogenous necrotic mass in the lesser sac likely arising from pancreatic body with possible infiltration of the stomach, left lobe of the liver and encasing celiac vessels and portal vein with multiple peripancreatic and retroperitoneal necrotic lymph nodes. Endoscopic ultrasound with fine-needle aspiration of pancreatic mass was done, biopsy specimen revealed the presence of inflammation with no evidence of malignancy. TB polymerase chain reaction and culture came positive for Mycobacterium tuberculosis. He was started on antituberculosis treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol with a plan to continue for total 6 months. However, follow-up of the patient could not be done as he traveled back to his home country.
尽管发展中国家结核病(TB)的患病率很高,但原发性胰腺结核是一种罕见的疾病。我们报告一例免疫功能正常的胰腺结核患者,该患者被发现有类似恶性肿瘤的胰腺肿块。一名40岁的印度男性因腹痛和发热2周就诊于急诊室。他在过去2个月中有意外体重减轻约20磅的病史。没有明显的接触结核病患者的病史。家族史中无任何恶性肿瘤病史。体检时,主要发现是上腹部压痛。对他进行了全面检查,其结核菌素纯蛋白衍生物和全血γ干扰素释放试验均为阴性。胸部X线检查无异常。进行了腹部计算机断层扫描,结果显示小网膜囊内有一个大的不均匀坏死肿块,可能起源于胰体,可能侵犯胃、肝左叶,包绕腹腔干血管和门静脉,伴有多个胰周和腹膜后坏死淋巴结。对胰腺肿块进行了内镜超声引导下细针穿刺,活检标本显示有炎症,无恶性肿瘤证据。结核聚合酶链反应和培养结果显示结核分枝杆菌阳性。他开始接受异烟肼、利福平、吡嗪酰胺和乙胺丁醇的抗结核治疗,计划总共持续6个月。然而,由于他返回了自己的国家,无法对该患者进行随访。