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Are we ready to use hypofractionated instead of conventional radiotherapy for prostate cancer? Not yet.我们准备好使用大分割放疗而非传统放疗来治疗前列腺癌了吗？还没有。
Int Braz J Urol. 2019 Jan-Feb;45(1):5-9. doi: 10.1590/S1677-5538.IBJU.2018.0734.
2
Elective Pelvic Nodal Irradiation With a Simultaneous Hypofractionated Integrated Prostate Boost for Localised Prostate Cancer: Ready for Prime Time?局部前列腺癌的选择性盆腔淋巴结放疗联合同期缩野前列腺加量放疗：是否已准备好应用于临床？
Clin Oncol (R Coll Radiol). 2020 Mar;32(3):181-188. doi: 10.1016/j.clon.2019.12.002. Epub 2020 Jan 8.
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Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer (HYPO-RT-PC): patient-reported quality-of-life outcomes of a randomised, controlled, non-inferiority, phase 3 trial.超分割与常规分割放疗治疗前列腺癌（HYPO-RT-PC）的比较：一项随机、对照、非劣效、3 期临床试验的患者报告的生活质量结局。
Lancet Oncol. 2021 Feb;22(2):235-245. doi: 10.1016/S1470-2045(20)30581-7. Epub 2021 Jan 11.
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Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer.局部前列腺癌患者应用内置式直肠气囊的中度低分割调强放疗的长期疗效。
Cancer Commun (Lond). 2018 Apr 17;38(1):11. doi: 10.1186/s40880-018-0281-4.
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PROshot: Internal Mammary Coverage, Dose-Reduced Radiation After Transoral Surgery, Sequencing of Total Neoadjuvant Therapy for Rectal Cancer, Hypofractionated Whole Breast Intensity Modulated Radiation Therapy, Hypofractionated Prostate Fossa Radiation Therapy, and Stereotactic Body Radiation Therapy for Oligoprogressive Cancer.PROshot：内乳覆盖、经口手术后剂量降低的放疗、直肠癌全新辅助治疗的序贯治疗、大分割全乳调强放疗、大分割前列腺窝放疗以及寡进展性癌的立体定向体部放疗
Pract Radiat Oncol. 2022 Mar-Apr;12(2):79-83. doi: 10.1016/j.prro.2021.12.010.
6
Prostate cancer: Moderate hypofractionated radiotherapy - not yet a standard of care.前列腺癌：中等程度的大分割放疗——尚未成为标准治疗方案。
Nat Rev Clin Oncol. 2016 Nov;13(11):655-656. doi: 10.1038/nrclinonc.2016.147. Epub 2016 Sep 20.
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Hypofractionated radiotherapy recommendations for localized prostate cancer in Brasil.巴西局部前列腺癌的适形分割放射治疗建议。
Rev Assoc Med Bras (1992). 2021 Jan;67(1):7-18. doi: 10.1590/1806-9282.67.01.002.
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Patient-reported Urinary, Bowel, and Sexual Function After Hypofractionated Intensity-modulated Radiation Therapy for Prostate Cancer: Results From a Randomized Trial.前列腺癌大分割调强放射治疗后患者报告的泌尿、肠道和性功能：一项随机试验的结果
Am J Clin Oncol. 2018 Jun;41(6):558-567. doi: 10.1097/COC.0000000000000325.
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Standard versus hypofractionated intensity-modulated radiotherapy for prostate cancer: assessing the impact on dose modulation and normal tissue effects when using patient-specific cancer biology.标准分割与大分割调强放射治疗前列腺癌：利用患者特异性癌症生物学评估对剂量调制和正常组织效应的影响。
Phys Med Biol. 2021 Feb 5;66(4):045007. doi: 10.1088/1361-6560/ab9354.
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Current status of intensity-modulated radiation therapy for prostate cancer: History, clinical results and future directions.前列腺癌调强放疗的现状：历史、临床结果和未来方向。
Int J Urol. 2019 Aug;26(8):775-784. doi: 10.1111/iju.14011. Epub 2019 May 21.

本文引用的文献

1
Hypofractionated Radiation Therapy for Localized Prostate Cancer: Executive Summary of an ASTRO, ASCO, and AUA Evidence-Based Guideline.局限性前列腺癌的分割放疗：ASTRO、ASCO 和 AUA 循证指南的执行摘要。
Pract Radiat Oncol. 2018 Nov-Dec;8(6):354-360. doi: 10.1016/j.prro.2018.08.002. Epub 2018 Oct 11.
2
Hypofractionated Radiation Therapy for Localized Prostate Cancer: An ASTRO, ASCO, and AUA Evidence-Based Guideline.局部前列腺癌的大分割放射治疗：美国放射肿瘤学会、美国临床肿瘤学会和美国泌尿外科学会循证指南
J Clin Oncol. 2018 Oct 11;36(34):JCO1801097. doi: 10.1200/JCO.18.01097.
3
Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics.《国家癌症报告：第一部分：全国癌症统计数据》
Cancer. 2018 Jul 1;124(13):2785-2800. doi: 10.1002/cncr.31551. Epub 2018 May 22.
4
Radiation treatment of prostate cancers - the contemporary role of modern brachytherapy techniques.前列腺癌的放射治疗——现代近距离放射治疗技术的当代作用。
J Contemp Brachytherapy. 2017 Oct;9(5):391-392. doi: 10.5114/jcb.2017.71034. Epub 2017 Oct 30.
5
Moderate Hypofractionation in High-Risk, Organ-Confined Prostate Cancer: Final Results of a Phase III Randomized Trial.中高危局限性前列腺癌的适度分割放疗：III 期随机试验的最终结果。
J Clin Oncol. 2017 Jun 10;35(17):1891-1897. doi: 10.1200/JCO.2016.70.4189. Epub 2017 Mar 29.
6
Randomized Trial of a Hypofractionated Radiation Regimen for the Treatment of Localized Prostate Cancer.随机分组试验：一种低分割辐射方案治疗局限性前列腺癌。
J Clin Oncol. 2017 Jun 10;35(17):1884-1890. doi: 10.1200/JCO.2016.71.7397. Epub 2017 Mar 15.
7
Long-Term Patient-Reported Outcomes From a Phase 3 Randomized Prospective Trial of Conventional Versus Hypofractionated Radiation Therapy for Localized Prostate Cancer.一项针对局限性前列腺癌的传统放疗与大分割放疗的3期随机前瞻性试验的长期患者报告结局
Int J Radiat Oncol Biol Phys. 2017 Mar 15;97(4):722-731. doi: 10.1016/j.ijrobp.2016.12.034. Epub 2016 Dec 28.
8
Stereotactic Ablative Radiotherapy Versus Low Dose Rate Brachytherapy or External Beam Radiotherapy: Propensity Score Matched Analyses of Canadian Data.立体定向消融放疗与低剂量率近距离放疗或外照射放疗的比较：加拿大数据的倾向评分匹配分析
Clin Oncol (R Coll Radiol). 2017 Mar;29(3):161-170. doi: 10.1016/j.clon.2016.10.001. Epub 2016 Oct 22.
9
Patient-reported Urinary, Bowel, and Sexual Function After Hypofractionated Intensity-modulated Radiation Therapy for Prostate Cancer: Results From a Randomized Trial.前列腺癌大分割调强放射治疗后患者报告的泌尿、肠道和性功能：一项随机试验的结果
Am J Clin Oncol. 2018 Jun;41(6):558-567. doi: 10.1097/COC.0000000000000325.
10
Hypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trial.局部前列腺癌患者的低分割与常规分割放疗（HYPRO）：一项随机、多中心、开放标签、3 期临床试验的最终疗效结果。
Lancet Oncol. 2016 Aug;17(8):1061-1069. doi: 10.1016/S1470-2045(16)30070-5. Epub 2016 Jun 20.

Are we ready to use hypofractionated instead of conventional radiotherapy for prostate cancer? Not yet.

作者信息

Pellizzon Antonio Cassio Assis

机构信息

Departamento de Radioterapia, Hospital AC Camargo Cancer Center, São Paulo, Brasil.

出版信息

Int Braz J Urol. 2019 Jan-Feb;45(1):5-9. doi: 10.1590/S1677-5538.IBJU.2018.0734.

DOI:10.1590/S1677-5538.IBJU.2018.0734
PMID:30860337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6442146/
Abstract
摘要