Musick Sierra R., Lynch David T.
SAMMC
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma composed of cytotoxic alpha-beta T-cells that mimics panniculitis. Distinction from the more aggressive primary cutaneous gamma delta T-cell lymphoma was made in the 2008 revision of the World Health Organization (WHO) Classification of Tumours of Hematopoietic and Lymphoid Tissues. Autoimmune diseases occur in approximately 20% of cases, and lupus erythematosus panniculitis (LEP) is usually part of the differential diagnosis due to similar clinical and histologic features. Histologically, the neoplastic CD8+, beta F1 expressing cytotoxic T-cells characteristically surround and disrupt individual adipocyte membranes (see Subcutaneous Panniculitis). Most cases have a good prognosis and follow an indolent clinical course; however, 15% to 20% of cases are complicated by hemophagocytic syndrome (HPS).
皮下脂膜炎样T细胞淋巴瘤（SPTCL）是一种罕见的原发性皮肤淋巴瘤，由细胞毒性α-βT细胞组成，可模仿脂膜炎。在2008年世界卫生组织（WHO）造血和淋巴组织肿瘤分类修订版中，它与侵袭性更强的原发性皮肤γδT细胞淋巴瘤得以区分。自身免疫性疾病约在20%的病例中出现，由于临床和组织学特征相似，狼疮性脂膜炎（LEP）通常是鉴别诊断的一部分。组织学上，肿瘤性CD8 +、表达βF1的细胞毒性T细胞特征性地围绕并破坏单个脂肪细胞膜（见皮下脂膜炎）。大多数病例预后良好，临床病程呈惰性；然而，15%至20%的病例会并发噬血细胞综合征（HPS）。
