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音乐节参与者的口腔液药物检测结果与自我报告的非法药物使用之间的关联性。

Correspondence between Oral Fluid Drug Test Results and Self-Reported Illicit Drug Use among Music Festival Attendees.

机构信息

a Section of Drug Abuse Research, Department of Forensic Sciences , Oslo University Hospital , Oslo , Norway.

b Department of Alcohol, Tobacco and Drugs , Norwegian Institute of Public Health , Oslo , Norway.

出版信息

Subst Use Misuse. 2019;54(8):1337-1344. doi: 10.1080/10826084.2019.1580295. Epub 2019 Mar 12.

DOI:10.1080/10826084.2019.1580295
PMID:30860932
Abstract

BACKGROUND

Use of illicit substances is often under-reported. Testing positive in oral fluid provides an objective confirmation of recent intake.

OBJECTIVES

To examine the agreement between oral fluid test results and self-reported substance use among music festival attendees, and factors associated with reporting past 48 h drug use among users identified by drug testing.

METHODS

One thousand three hundred nine participants were recruited from six music festivals in Norway (June-August 2016). They completed a questionnaire and provided oral fluid samples analyzed for amphetamines, MDMA, tetrahydrocannabinol (cannabis), and cocaine. Additionally, their blood alcohol levels were measured.

RESULTS

Overall, 5.5% reported use of amphetamines, cannabis, cocaine, and/or MDMA during past 48 h in the questionnaire, whereas 10.8% tested positive in oral fluid. Only 16.7% of identified cocaine users and 31.1% of identified MDMA users reported past 48 h cocaine or MDMA use, respectively. Higher proportions of identified cannabis and amphetamine users reported past 48 h use (53.8% and 55.6%, respectively). Multivariable logistic regression analysis showed that among participants who tested positive, those reporting weekly illicit substance use (Adjusted Odds Ratio [AOR] 30.6; 95% Confidence Interval [CI] 6.3-147.9), and using such substances when younger than 18 years (AOR 5.0; 95% CI 1.9-13.4) were more likely to report past 48 h use. Conclusions/Importance: Oral fluid testing appears to be an important tool when studying illicit substance use among music festival attendees, as significant under-reporting was observed. Among those testing positive, regular, and experienced users were more likely to report recent use, compared to less regular and experienced users.

摘要

背景

非法物质的使用通常报告不足。口腔液检测呈阳性可客观证实近期摄入情况。

目的

检验音乐节参与者口腔液检测结果与自我报告物质使用情况之间的一致性,以及与药物检测确定的药物使用者报告过去 48 小时内用药情况相关的因素。

方法

2016 年 6 月至 8 月,从挪威六个音乐节中招募了 1309 名参与者。他们完成了一份问卷并提供了口腔液样本,样本经分析后可检测到安非他命、MDMA、四氢大麻酚(大麻)和可卡因。此外,还测量了他们的血液酒精水平。

结果

总体而言,5.5%的参与者在问卷中报告过去 48 小时内使用过安非他命、大麻、可卡因和/或 MDMA,而 10.8%的人在口腔液中检测呈阳性。只有 16.7%的可卡因使用者和 31.1%的 MDMA 使用者报告过去 48 小时内使用过可卡因或 MDMA。更多的大麻和安非他命使用者报告过去 48 小时内使用过这些药物(分别为 53.8%和 55.6%)。多变量逻辑回归分析显示,在检测呈阳性的参与者中,报告每周使用非法物质(调整后的优势比[OR]30.6;95%置信区间[CI]6.3-147.9)和 18 岁以下使用此类物质(OR 5.0;95%CI 1.9-13.4)的参与者更有可能报告过去 48 小时内使用过药物。

结论/意义:口腔液检测似乎是研究音乐节参与者非法物质使用情况的重要工具,因为观察到了明显的漏报。与使用频率较低和经验较少的使用者相比,检测呈阳性、经常使用和经验丰富的使用者更有可能报告近期使用情况。

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