一种用于胰腺外分泌功能诊断的放射性药物：胰腺中62Zn-EDDA的代谢

A radiopharmaceutical for pancreatic exocrine functional diagnosis: 62Zn-EDDA metabolism in pancreas.

作者信息

Fujibayashi Y, Saji H, Kawai K, Unuma Y, Miyata S, Okuno T, Hosotani R, Inoue K, Adachi H, Horiuchi K

出版信息

Int J Nucl Med Biol. 1986;12(6):447-51.

Abstract

The metabolic pathway of radioactive 62Zn-EDDA (ethylenediamine-N,N'-diacetic acid), in the exocrine pancreas was studied with respect to that of endogenous Zn. In pancreatic duct cannulated dog, the secretion of intravenously injected exogenous 62Zn into pancreatic juice increased under the stimulation of CCK-PZ (pancreatic protein secretion stimulating hormone), which closely correlated to endogenous Zn. Moreover, in pancreatic juice, 62Zn as well as endogenous Zn was selectively bound to Zn-metalloenzymes, carboxypeptidase A and B. These results demonstrated the close correlation between the endogenous and the exogenously-administered Zn (62Zn-EDDA), as well as the high availability of 62Zn-EDDA as a marker of pancreatic function for the follow up of carboxypeptidase metabolism.

摘要

就外分泌胰腺中放射性62Zn-乙二胺-N,N'-二乙酸（EDDA）的代谢途径与内源性锌的代谢途径进行了研究。在胰管插管的犬中，静脉注射的外源性62Zn在促胰液素-胰酶泌素（CCK-PZ，刺激胰腺蛋白质分泌的激素）刺激下，向胰液中的分泌增加，这与内源性锌密切相关。此外，在胰液中，62Zn以及内源性锌选择性地与锌金属酶、羧肽酶A和B结合。这些结果表明内源性锌与外源性给予的锌（62Zn-EDDA）之间密切相关，以及62Zn-EDDA作为羧肽酶代谢后续胰腺功能标志物的高可用性。