62锌-乙二胺二乙酸：一种用于胰腺功能诊断的放射性药物。

62Zn-EDDA: a radiopharmaceutical for pancreatic functional diagnosis.

作者信息

Fujibayashi Y, Saji H, Yomoda I, Kawai K, Horiuchi K, Adachi H, Torizuka K, Yokoyama A

出版信息

Int J Nucl Med Biol. 1986;12(6):439-46. doi: 10.1016/s0047-0740(86)80005-5.

Abstract

As Zn is closely associated with the exocrine and endocrine functions of the pancreas, exploitation of Zn metabolism for anatomical and functional diagnosis was conceived, namely with the recent availability of positron emitting 62Zn (t1/2 = 9 h). In the present paper, response changes in Zn biodistribution (mice) and Zn excretion through the pancreatic duct (rats) due to the stimulation of gastro-intestinal hormones like secretin, CCK-PZ (exocrine stimulation) and glucose (endocrine stimulation) were studied. Under these stimuli, the pancreatic secretion of radioactive Zn through cannulated pancreatic duct showed increased Zn secretion only under the CCK-PZ effect, 3 h post 65Zn (t1/2 = 270 d) injection. Tissue biodistribution in mice pre-injected with 65Zn showed pancreas specific decrease of radioactive Zn whenever a gastro-intestinal hormone was post-administered, whereas the glucose effect was negligible. Thus, the effective mobilization of the injected radioactive Zn, upon exocrine stimulation, represented by CCK-PZ, favored the exploration of a functional study of the pancreas with the positron computed tomograph (PCT) using short lived nuclide labeled 62Zn-EDDA in dog. Evidence of the applicability of this system in regional function studies of the pancreas was obtained. Demonstration of Zn participation in the exocrine function of the pancreas in-vivo holds considerable promise for diagnosis of pancreatic diseases.

摘要

由于锌与胰腺的外分泌和内分泌功能密切相关，因此人们设想利用锌代谢进行解剖学和功能诊断，即利用最近可用的发射正电子的62锌（半衰期=9小时）。在本文中，研究了由于促胰液素、胆囊收缩素-促胰酶素（外分泌刺激）和葡萄糖（内分泌刺激）等胃肠激素的刺激，锌在生物体内分布（小鼠）的反应变化以及锌通过胰管的排泄（大鼠）情况。在这些刺激下，通过插管胰管分泌的放射性锌仅在注射65锌（半衰期=270天）3小时后，在胆囊收缩素-促胰酶素的作用下锌分泌增加。预先注射65锌的小鼠组织生物分布显示，无论何时给予胃肠激素，胰腺中放射性锌都会出现特异性减少，而葡萄糖的影响可忽略不计。因此，以胆囊收缩素-促胰酶素为代表的外分泌刺激下，注射的放射性锌的有效动员，有利于使用短寿命核素标记的62锌-乙二胺-N,N'-二乙酸在狗身上用正电子计算机断层扫描（PCT）对胰腺进行功能研究。获得了该系统在胰腺区域功能研究中适用性的证据。证明锌在胰腺外分泌功能中的体内参与对胰腺疾病的诊断具有很大的前景。