Martynova L E, Belousov L V
Ontogenez. 1978;9(4):382-9.
The effect of antagonists of biogenous amines (antitransmitters--AT) and colchicine on rapid morphogenetic processes in the explants of embryonic ectoderm with underlying mesoderm cut from the lateral region of Rana temporaria embryos at the late neurula-early taibud stages was studied. The normal morphogenesis of the explants consists of two successive phases: phase of contact polarization and phase of cell movement into the fragment. The high concentrations of AT inhibited completely the morphogenesis of explants but somewhat lower concentrations inhibited the second phase of morphogenesis and not only did not prevent the cell polarization but even assisted its propagation over all the fragment. The inhibiting effect of AT was relieved by 5-hydroxytryptamine which per se stimulated the morphogenesis of explants. Thus, AT exert a specific inhibition of the motility of embryonic cells but do not prevent the contact interactions responsible for cell polarization within every layer.
研究了生物源胺拮抗剂（抗递质——AT）和秋水仙碱对从林蛙胚胎侧区在神经胚晚期至早期尾芽期切下的带有下方中胚层的胚胎外胚层外植体快速形态发生过程的影响。外植体的正常形态发生包括两个连续阶段：接触极化阶段和细胞向片段内移动阶段。高浓度的AT完全抑制外植体的形态发生，但稍低浓度则抑制形态发生的第二阶段，不仅不阻止细胞极化，甚至有助于其在整个片段上传播。5-羟色胺可缓解AT的抑制作用，5-羟色胺本身可刺激外植体的形态发生。因此，AT对胚胎细胞的运动性有特异性抑制作用，但不阻止负责各层内细胞极化的接触相互作用。
