From "high" ZEB1 to "low" B-cell lymphoma 2-interacting mediator of cell death (BIM)-an epithelial-mesenchymal transition (EMT)-associated drug resistance pathway elucidated.
作者信息
Marcucci Fabrizio, Rumio Cristiano
机构信息
Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
出版信息
J Thorac Dis. 2019 Jan;11(1):1-5. doi: 10.21037/jtd.2018.12.70.
Abstract
摘要
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From "high" ZEB1 to "low" B-cell lymphoma 2-interacting mediator of cell death (BIM)-an epithelial-mesenchymal transition (EMT)-associated drug resistance pathway elucidated.从“高”ZEB1到“低”细胞死亡的B细胞淋巴瘤2相互作用介质（BIM）——一种上皮-间质转化（EMT）相关的耐药途径得以阐明。
J Thorac Dis. 2019 Jan;11(1):1-5. doi: 10.21037/jtd.2018.12.70.
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Front Med. 2018 Aug;12(4):361-373. doi: 10.1007/s11684-018-0656-6. Epub 2018 Jul 24.
2
How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress-Therapeutic Implications.肿瘤细胞如何在上皮-间质转化和自噬之间做出选择以抵抗应激——治疗意义
Front Pharmacol. 2018 Jul 2;9:714. doi: 10.3389/fphar.2018.00714. eCollection 2018.
3
Identification of the tumour transition states occurring during EMT.鉴定 EMT 过程中发生的肿瘤过渡状态。
Nature. 2018 Apr;556(7702):463-468. doi: 10.1038/s41586-018-0040-3. Epub 2018 Apr 18.
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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.耐药物持久性癌细胞易受谷胱甘肽过氧化物酶4（GPX4）抑制的影响。
Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1.
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Tumor cell-associated immune checkpoint molecules - Drivers of malignancy and stemness.肿瘤细胞相关免疫检查点分子 - 恶性肿瘤和干细胞特性的驱动因素。
Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):571-583. doi: 10.1016/j.bbcan.2017.10.006. Epub 2017 Oct 19.
6
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM.上皮-间充质转化通过抑制 BIM 拮抗肺癌对靶向治疗的反应。
Clin Cancer Res. 2018 Jan 1;24(1):197-208. doi: 10.1158/1078-0432.CCR-17-1577. Epub 2017 Oct 19.
7
ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.ZEB1诱导LOXL2介导的胶原蛋白在细胞外基质中稳定和沉积，以驱动肺癌的侵袭和转移。
Oncogene. 2017 Apr 6;36(14):1925-1938. doi: 10.1038/onc.2016.358. Epub 2016 Oct 3.
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Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells.上皮-间质转化诱导的组织因子引发促凝状态，驱动循环肿瘤细胞转移。
Cancer Res. 2016 Jul 15;76(14):4270-82. doi: 10.1158/0008-5472.CAN-15-2263. Epub 2016 May 24.
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Epithelial-mesenchymal transition: a new target in anticancer drug discovery.上皮-间质转化：抗肿瘤药物研发的新靶点。
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