De Feo M L, Maggi M, Guardabasso V, Rodbard D, Delitala G, Fazzi V, Genazzani A D, Facchinetti F, Forti G
J Clin Endocrinol Metab. 1986 Jul;63(1):257-61. doi: 10.1210/jcem-63-1-257.
Naloxone administration has no effect on plasma gonadotropin levels of agonadal men. The present study was designed to evaluate whether testosterone replacement therapy could restore LH responsiveness to naloxone in such men. We measured plasma LH and FSH levels at 15-min intervals during naloxone infusion (8 mg in 1 min followed by 12 mg in 3 h) and for the following 3 h in a group of agonadal men both before and after at least 2 months of three different schedules of testosterone replacement therapy: 1) testosterone undecanoate, 40 mg three times a day by mouth; 2) testosterone enanthate 200 mg im every 2 weeks; and 3) testosterone enanthate 100 mg im once a week. Mean plasma gonadotropin levels as well as LH pulse frequency did not vary during naloxone infusion vs. placebo either basally or during each testosterone regimen. These results suggest that long term testosterone therapy does not affect the altered opioid modulation of gonadotropin secretion which is present in agonadal men.
给予纳洛酮对性腺功能减退男性的血浆促性腺激素水平没有影响。本研究旨在评估睾酮替代疗法是否能恢复此类男性对纳洛酮的促黄体生成素（LH）反应性。我们在一组性腺功能减退男性中，于纳洛酮输注期间（1分钟内输注8毫克，随后3小时内输注12毫克）以及之后的3小时内，每隔15分钟测量一次血浆LH和促卵泡生成素（FSH）水平，测量时间分别为至少2个月的三种不同睾酮替代治疗方案之前和之后：1）十一酸睾酮，口服，每日三次，每次40毫克；2）庚酸睾酮，每2周肌肉注射200毫克；3）庚酸睾酮，每周肌肉注射100毫克。在基础状态以及每种睾酮治疗方案期间，与安慰剂相比，纳洛酮输注期间的平均血浆促性腺激素水平以及LH脉冲频率均无变化。这些结果表明，长期睾酮治疗不会影响性腺功能减退男性中存在的促性腺激素分泌的阿片类物质调节改变。
