用于耐药性测定的全基因组测序在……中
Whole genome sequencing for drug resistance determination in .
作者信息
Omar Shaheed V, Joseph Lavania, Said Halima M, Ismail Farzana, Ismail Nabila, Gwala Thabisile L, Ismail Nazir A
机构信息
Centre for Tuberculosis, World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
Department of Medical Microbiology, University of the Free State, Bloemfontein, South Africa.
出版信息
Afr J Lab Med. 2019 Feb 21;8(1):801. doi: 10.4102/ajlm.v8i1.801. eCollection 2019.
South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in with the provision of information for several drugs simultaneously.
南非仍然面临着结核病负担沉重以及耐药病例增加的挑战。我们评估了Illumina MiSeq（一种用于全基因组测序的新一代测序平台）的使用情况，随后使用商业软件包进行生物信息分析，以确定对我们所在地区治疗所用特定药物的耐药性。全基因组测序显示出作为检测耐药性的诊断平台的潜力，可同时提供多种药物的信息。
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